Guoqiang Chen,Chief Scientist of the National Key Basic Research (973) Program, and National Candidate for the "Hundreds and Thousands of Talents Project",1999-2001, engaged in cooperative research at the Mount-Saint Medical School of USA

 Chen Guoqiang, male, born in 1963, from Youxian County, Hunan Province, Ph.D., is currently the Vice Dean of Shanghai Jiaotong University School of Medicine, Dean of the Academy of Medical Sciences and Dean of the Graduate School, Director of the Key Laboratory of Cell Differentiation and Apoptosis of the Ministry of Education, Director of the Department of Pathophysiology, Executive Director of the Chinese Society of Pathophysiology, Vice Chairman of the Shanghai Society of Biochemistry and Molecular Biology, Vice Chairman of the Shanghai Physiological Society, Deputy Editor-in-Chief of Acta Physiologica Sinica, Cancer, and International Journal of Pathology and Clinical Sciences , "OpenHematologyJ", "ActaPharmacologySina", "Chinese Medical Journal", "Science Bulletin", "China Science-Life Science Series", "Chinese Journal of Cancer Biotherapy", "Chinese Journal of Cancer Prevention and Treatment" and other editorial board members. Winner of the National Science Fund for Distinguished Young Scholars, Chief Scientist of the National Key Basic Research (973) Program, and National Candidate for the "Hundreds and Thousands of Talents Project". In July 1996, he obtained a doctorate in medicine from Shanghai Second Medical University (now Shanghai Jiaotong University School of Medicine), and in 1997 and 1999-2001, he engaged in cooperative research at the Saint-Louis Hospital in Paris, France, and the Mount-Saint Medical School in the United States. 

　　For many years, he has been devoted to the molecular mechanism and basic therapeutic research of leukemia cell differentiation and apoptosis. His basic and clinical research work on the treatment of acute promyelocytic leukemia with arsenic trioxide has attracted great attention from international counterparts. After returning to China in May 2002 and serving as the director of the pathophysiology teaching and research section of Shanghai Jiaotong University School of Medicine, a teaching and research section with only ten employees, less than 10,000 yuan of scientific research assets, and no scientific research projects has achieved leap-forward development. In the past few years, on the basis of his discovery of hypoxia-induced leukemia cell differentiation, he proposed a signaling mechanism for leukemia cell differentiation based on "hypoxia-hypoxia-inducible factor (HIF-1a)-C/EBPa"; reported that phospholipid crawling enzyme-mediated It can induce leukemia differentiation and make new discoveries on its expression regulation mechanism; it is found that a new type of camptothecin derivative NSC606985 can induce leukemia cell apoptosis at low concentrations, and its mechanism of inducing apoptosis has been studied, showing good results. Prospects for drug development. In addition, important progress has also been made in the use of proteomic techniques to study the functions of leukemia-related proteins.

　　So far, he has published more than 60 papers in important international academic journals such as JNCI, BLOOD, JBC, ONCOGENE, LEUKEMIA, CANCERRES, etc. Since 1997, it has always been in the top eight in the national ranking of single paper citations, with a total of more than 2,700 times. He has also successively won the second prize of the National Natural Science Award, the first prize of the Shanghai Science and Technology Progress Award, the DuPont Science and Technology Innovation Award, the China Youth Science and Technology Award, the first prize of the Shanghai Medical Science and Technology Award, the China Medical Science and Technology Award and other academic awards and national and Shanghai model workers. , the first batch of candidates for the National Hundred Thousand Talents Project in the New Century, Shanghai Science and Technology Talents, Shanghai Outstanding Discipline Leader, Shanghai Natural Science Peony Award and other honorary titles.

 

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Wednesday, January 19, 2022Today is:President's speech

Alumni Association President to 2011...

　　Tian Xingjian, unremitting self-improvement, Longteng medicine has a broad road; terrain is Kun, great virtue carries things, Lin Tuyushu is a new beginning. May the teachings of Boji Hospital, diligent and tireless continue to guide you, not to admire the impetuous publicity, but to be willing to serve in loneliness.

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Chen Guoqiang, born in November 1963, is a professor of medical pathophysiology and an academician of the Chinese Academy of Sciences. He is currently the dean of Shanghai Jiaotong University School of Medicine, deputy secretary of the party committee, vice president of Shanghai Jiaotong University, and representative of the 15th Shanghai Municipal People's Congress.                              

     

Professor Chen Guoqiang graduated from the former Shanghai Second Medical University in 1988 and 1996 with a master's degree in medicine and a doctorate in medicine, respectively. On July 1, 1997, he joined the Communist Party of China. In 1997 and 1999-2001, he was a visiting scholar in Paris, France and New York, USA respectively.                              

     

Since he was awarded the National Science Fund for Distinguished Young Scholars in 1997, especially since he served as the director of the Pathophysiology Teaching and Research Section of Shanghai Second Medical University in 2002, he has taken the lead and worked hard, successively as the chief scientist to undertake the National Key Basic Research (973) Project and the National Major Scientific Research Planning projects, and as the leader of a number of key projects of the National Natural Science Foundation of China, major projects and leaders of innovation groups, leading research teams, dedicated to tumor, especially acute myeloid leukemia (AML) cell fate determination and tumor microenvironment regulation mechanism Research. In terms of hypoxic microenvironment, it was found that hypoxia induces AML cell differentiation through the non-transcriptional function of hypoxia-inducible factor-1 (HIF-1), and revealed that Cbx4 modifies HIF-1α through ubiquitination to control hepatocellular carcinoma angiogenesis In the aspect of stress microenvironment, the mechanism of leukemia stem/progenitor cells to induce differentiation of bone marrow mesenchymal cells to form a new bone marrow microenvironment and the mechanism of environmental protection of leukemia cells in this microenvironment were discovered; in the aspect of chemical biology, it was found that Several antitumor natural compounds, especially adenine, were found to induce AML cell differentiation by targeting members of the peroxidoreductase family. Relevant research results have published more than 160 SCI papers in important international academic journals such as Cancer Cell, Nat Chem Biol, J Clin Invest, Nat Cell Biol, Blood, Leukemia, EMBO Report, Oncogene and other journals, and have been cited more than 7,000 times by him. He has successively won the second prize of the National Natural Science Award, the first prize of the Chinese Medical Science and Technology Award, the first prize of the Shanghai Natural Science Award, and the first prize of the Shanghai Science and Technology Progress Award. Young Expert, National Excellent Doctoral Dissertation Instructor, National Advanced Worker, Changjiang Distinguished Professor of the Ministry of Education, the first batch of national candidates for the New Century Hundred Thousand Talents Project, China Youth Science and Technology Award, Shanghai Model Worker, Shanghai Top Ten Outstanding Young People , Shanghai Science and Technology Talents, Shanghai Excellent Returnees from Overseas Study, Shanghai Medical Leading Talents, Shanghai Natural Science Peony Award and other honorary titles. He has also been invited to serve as the editorial board of many academic journals at home and abroad and honorary professors such as the University of Sydney and the University of Ottawa. Association Member of the Steering Committee of Academic Health Centers International.                              

     

In 2006 and 2010, Professor Chen Guoqiang served as the vice dean of the medical school in charge of scientific research and graduate students and the dean of the medical school in charge of administrative work respectively. He has always followed the development law of comprehensive universities, followed the special laws of medical disciplines, and set an example. , with the passion and perseverance of "success does not have to be mine, and skill must not be donated", determined to reform, committed to the discipline construction of "world-class, Chinese characteristics, Shanghai style and medical characteristics" and outstanding medical innovation talents with soul Cultivation work. He has always emphasized that through both introduction and education, talents are selected and used well, and the vitality of talents is activated. Motivating each other and transcending together, making students more excellent, making teachers more outstanding, and producing innovative ability and wisdom that will benefit both teachers and students for life." The innovative culture of passion, dreams and determination builds a synergistic and inclusive development system of teaching, scientific research, medical treatment and management, and realizes the rapid development of the medical school.                              

     

Dean Chen Guoqiang was an associate researcher, researcher (1997-2002) and deputy director (2001-2002) of Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Second Medical University, Basic Medicine of Shanghai Second Medical University/Shanghai Jiaotong University Director of the Department of Pathophysiology (2002-2009), Deputy Dean of Shanghai Jiaotong University School of Medicine (2006-2010), Dean of the Graduate School (2006-2009), and concurrently dean of the School of Basic Medicine and the Academy of Medical Sciences (2007-2010).