Scientific Program of Prion 2024 China

Scientific Program of Prion 2024
10/23/2024 Parallel Workshops
Workshops 1: Epidemiology of Prion Diseases and Pathogenesis of Neurodegenerative Diseases Hall A
Time Title Speaker
13:00 - 13:10 Welcome Remarks (Chairs: Xiaoping Dong & Jesús R. Requena)
13:10 - 13:30 Prion disease surveillance in the United States Ryan A. Maddox
CDC, USA zzp7@cdc.gov
13:30 - 13:50 Characteristics of human prion diseases in China
based on surveillance data
Qi Shi
CDC, China shiqi76@126.com
13:50 - 14:10
An update on surveillance of human prion diseases in
Australia
Christiane Stehmann
Australian National CJD Registry,
Australia
christiane.stehmann@florey.edu.au
14:10 - 14:30
Different classical scrapie and CWD strains circulating
in Europe as shown by prion strain typing using
ovinized mice (Tgshp IX)
Sonja Ernst
Friedrich-Loeffer-Institut, Germany
sonja.ernst@fli.de
14:30 - 14:50
Isolation of infectious, oligomeric prions from human
and animal prion diseases
Ilaria Vanni
Istituto Superiore di Sanità, Italy
ilaria.vanni@iss.it
14:50 - 15:10
New tools and insights to reveal the full picture of the
endogenous PrP shedding by the metalloprotease
ADAM10
Hermann Clemens Altmeppen
University Medical Center Hamburg,
Germany h.altmeppen@uke.de
15:10 - 15:25 Coffee Break
15:25 - 15:35 Welcome Remarks (Chairs: Jiyan Ma & Richard Knight)
15:35 - 15:55 The role of plasmin in PrPSc propagation
Chongsuk Ryou
Hanyang University, Korea
cryou2@hanyang.ac.kr
15:55 - 16:15 Identification and characterization of amyloidogenic
proteins within the human proteome
Aleksander Rubel
Saint Petersburg State University,
Russia arubel@mail.ru
16:15 -16:35
The cellular prion protein antagonist PSCMA prolongs
survival and reduces microglia dysregulation in the
RML prion disease mouse model
Yue Wang
University Medical Center Hamburg-
Eppendorf, Germany
yuewang306@gmail.com
16:35 - 16:55 Experimental transmission of protease sensitive
prionopathy (VPSPr) to nonhuman primates
Jacqueline Mikol
Paris Diderot University, France
jacqueline.mikol@wanadoo.fr
16:55 - 17:15 Mechanism of misfolding of the mammalian prion
protein
Jayant Udgaonkar
Indian Institute of Science Education
and Research, India
jayant@iiserpune.ac.in
17:15 - 17:25 Closing Remarks
17:30 - 19:30 Dinner
Workshops 2: Diagnostic Biomarkers of Prion and Prion-like Diseases Hall B
Time Title Speaker
13:00 - 13:10 Welcome Remarks (Chairs: Jason Bartz & Zhijun Luo)
13:10 - 13:30 α-Synuclein aggregation and propagation in
Parkinson’s disease
Taku Hatano
Juntendo University, Japan
thatano@juntendo.ac.jp
13:30 - 13:50 Research progress on α-Synuclein RT-QuIC
Jianwen Deng
Peking University First Hospital,
China
jianwendeng@pkufh.com
13:50 - 14:10 Propagation of the prion pathology in the brain as
seen with MRI
Alberto Bizzi
Carlo Besta Neurological Institute,
Italy
alberto.bizzi@istituto-besta.it
14:10 - 14:30 Blood-based Alzheimer's biomarkers: advancements
and applications in Parkinson's disease
Huifang Shang
West China Hospital of Sichuan
University, China
hfshang2002@126.com
14:30 - 14:50
14-3-3 as a useful biomarker in the process of
developing the method of real-time quaking induced
conversion (RT-QuIC) for prion disease identification
Keding Cheng
Guangzhou Medical University,
China
zb-chengkeding@kingmed.com.cn
14:50 - 15:10
Autophagy regulates α-Synuclein trans-synaptic
propagation and induces dopaminergic neuron
functional deficits in drosophila
Wen Li
China Medical University, China
wli87@cmu.edu.cn
15:10 - 15:25 Coffee Break
15:25 - 15:35 Welcome Remarks (Chairs: Christina Orrú & Xiaofen Chen)
15:35 - 15:55 Is weight gain an early sign of sporadic Creutzfeldt-
Jakob disease?
Laura J. Ellett
University of Melbourne, Australia
laura.ellett@florey.edu.cn
15:55 - 16:15
Revealing the characteristics and early diagnosis of
Alzheimer’s disease using fluid and neuroimaging
markers
Tengfei Guo
Peking University Shenzhen
Graduate School, China
tengfei.guo@pku.edu.cn
16:15 -16:35
Detection of skin α-Synuclein using RT-QuIC as a
diagnostic biomarker for Parkinson's disease in the
Chinese population
Haiyang Luo
The First Affiliated Hospital of
Zhengzhou University, China
fccluohy@zzu.edu.cn
16:35 - 16:55
The diagnostic value of new technologies for
amplifying misfolded protein seeds in central motor
disorders
Pingyi Xu
The First Affiliated Hospital of
Guangzhou Medical University,
China pingyixu@sina.com
16:55 - 17:15
Developing enhanced RT-QuIC for detection of serum
tau-seeding activity as a diagnostic biomarker of
Alzheimer’s disease
Yirong Yang
The First Affiliated Hospital of
Nanchang University, China
yangyirong19@qq.com
17:15 - 17:25 Closing Remarks
17:30 - 19:30 Dinner
Workshops 3: Prion Diseases and Related Disorders Hall C
Time Title Speaker
13:00 - 13:10 Welcome Remarks (Chairs: Tiago Fleming Outeiro & Xiaoxin Yan)
13:10 - 13:30 The genetic causes and pathogenesis of PolyG diseases
Daojun Hong
The First Affiliated Hospital of
Nanchang University, China
hongdaojun@hotmail.com
13:30 - 13:50 Intermediate-length GGC repeat expansion in
NOTCH2NLC was identified in Chinese ALS patients
Dongsheng Fan
Peking University Third Hospital,
China dsfan@sina.com
13:50 - 14:10 14:10 - 14:30
14:30 - 14:50 14:50 - 15:10
15:10 - 15:25 15:25 - 15:35 15:35 - 15:55
15:55 - 16:15 16:15 -16:35
16:35 - 16:55
16:55 - 17:15
17:15 - 17:35 17:35 - 17:50 17:50 - 20:30 Condensation of cellular prion protein guides the TBK1-
IRF3 signaling pathway to promote renal fibrosis
Jing Nie
Peking University, China
jingnie2006@163.com
Cellular prion protein controls DNA damage response
and fibrosis following kidney injury by interacting with
epithelial growth factor receptor
Nana Song
Zhongshan Hospital, Fudan
University, China
song.nana@zs-hospital.sh.cn
Src-phosphorylated PrP traps TBK1 to inhibit the
activation of the innate immunity
Chao-Yang Li
Guangzhou Medical University,
China chaoyangli@gzhmu.edu.cn
Excess PrPC inhibits muscle cell differentiation via
miRNA-enhanced liquid–liquid phase separation
implicated in myopathy
Yi Liang
Wuhan University, China
liangyi@whu.edu.cn
Coffee Break
Welcome Remarks (Chairs: Eric Vallabh Minikel & Yue Huang)
Molecular mechanism of strain-distinct α-Synuclein and
tau cross-seeding uncovered by correlative approach
with O-PTIR super-resolution imaging
Jia-Yi Li
China Medical University, China
jia-yi.li@cmu.edu.cn
Structural studies of De Novo formation of [PSI+]
Ziang Wang
University College London, UK
z.wang@prion.ucl.ac.uk
Single intravenous treatment with Zinc finger repressor
leads to brain-wide reduction of prion in nonhuman
primates and significantly prolongs survival in the RML
mouse model
Shih-Wei Chou
Sangamo Therapeutics Inc. USA
vchou@sangamo.com
Light identification of protein suppressors (LIPS) as a
new technology to screen for genetic and
pharmacological modulators of the cellular prion
protein
Emiliano Biasini
University of Trento, Italy
emiliano.biasini@unitn.it
Vaccines that imitate the structural epitopes on α-
Synuclein fibrils offer protection against Parkinson’s
disease
Erdem Gültekin Tamgüney
University of Alberta, Canada
erdem@hhu.de
Rationally designed, structure-based vaccine candidates
targeting chronic wasting disease
Andrew Fang
University of Alberta, Canada
jfang5@ualberta.ca
Closing Remarks
Dinner
10/24/2024, Main Hall
Opening Session (Chairs: Jianming Li & Bing-Xing Pan)
Time Title Speaker
08:30 - 08:50 Welcome Remarks
Leaders from Provincial
Government, Nanchang
University and NeuroPrion
Association
08:50 - 09:00 Group Photography All invited guests
Plenary Speech (Chairs: Giuseppe Legname & Jialin Zheng)
Stanley B. Prusiner
University of California San
09:00 - 10:00 The expanding prion paradigm
Francisco, USA
stanley.prusiner@ucsf.edu
Session 1: Prion Strains: From Molecular Structures to Disease Diversity
(Chairs: Jean-Philippe Deslys & Weidong Le)
Keynote Speeches
10:00 - 10:25 Decoding PrP misfolding: Learning from nature to design
the future
Joaquín Castilla
CIC bioGUNE, Spain
jcastilla@cicbiogune.es
10:25-10:50 Critical gatekeepers in mammalian prion infection
Peter-Christian Klöhn
University College London, UK
p.kloehn@prion.ucl.ac.uk
10:50 - 11:05 Coffee Break
Oral Presentations (selected from abstracts)
11:05 - 11:20 Transmission of VPSPr in macaque: An open gate to
prion-like diseases?
Emmanuel E. Comoy
CEA-Prion Research Unit, France
emmanuel.comoy@cea.fr
11:20 - 11:35 High resolution structures of brain-derived prion strains
Parvez Alam
National Institutes of Health, USA
parvez.alam@nih.gov
11:35 - 11:50
Exploring the complex role of cofactors in prion strain
diversity: Distinct polysaccharides generate unique
recombinant PrPSc conformers
Hasier Eraña
CIC bioGUNE, Spain
herana.atlas@cicbiogune.es
12:00 - 13:30 Lunch
13:30 - 14:30 14:30 - 14:55
14:55 - 15:20 15:20 - 15:45 15:45 - 16:00 16:00 - 16:15
16:15 - 16:30 16:30 - 16:55 16:55 - 17:20 Plenary Speech (Chairs: Yang Shi & Holger Wille)
Cryo-EM structures of amyloid filaments from human
brains
Michel Goedert
University of Cambridge, UK
mg@mrc-lmb.cam.ac.uk
Session 2: Advances in Pathogenic, Diagnostic, and Therapeutic Studies
(Chairs: Hidehiro Mizusawa & Rujing Ren)
Keynote Speeches
Novel diagnostic and prognostic approach for rapidly
progressive dementias: Indicators based on
amyloid/tau/neurodegeneration (ATN) framework
Jintai Yu
Huashan Hospital Affiliated to
Fudan University, China
jintai_yu@fudan.edu.cn
Distinct tau fibril types and their role in prion diseases
Giuseppe Legname
Scuola Internazionale Superiore
di Studi Avanzati, Italy
giuseppe.legname@sissa.it
Induced neural stem cell-derived extracellular vesicles:
New therapeutic strategy of neurological diseases
Jialin Zheng
Tongji University, China
jialinzheng@tongji.edu.cn
Coffee Break
Oral Presentations (selected from abstracts)
The purely thermodynamic anti-prionic mode of action
for the treatment of all neurodegenerative diseases,
including CJD
Dieter Willbold
Forschungszentrum Jülich,
Germany
d.willbold@fz-juelich.de
Syntaxin-6 modifies prion pathogenesis in vivo & in
cellular models
Elizabeth Hill
University College London, UK
e.hill@prion.ucl.ac.uk
Session 3: Advances in Therapeutic Studies
(Chairs: Hermann Clemens Altmeppen & Zhentao Zhang)
Keynote Speeches
Engineering the next generation of PrP-lowering
therapeutics
Eric Vallabh Minikel
Broad Institute, USA
eminikel@broadinstitute.org
TREM2 in the pathogenesis and targeted therapy of
Alzheimer’s disease
Xiaofen Chen
Xiamen University, China
chenxf@xmu.edu.cn
17:20 - 17:45 Translating structural biology into rationally-designed
vaccines for neurodegenerative diseases
Holger Wille
University of Alberta, Canada
wille@ualberta.ca
17:45 - 18:45 Poster Session
18:45 - 20:30 Welcome Reception & The 20th Anniversary Celebration of NeuroPrion
Chairs: Jean-Philippe Deslys & Wen-Quan Zou
10/25/2024, Main Hall
Plenary Speech (Chairs: Wen-Quan Zou & Hermann Schaetzl)
Time Title Speaker
08:30 - 09:30 Human prion diseases: Past, present, and a glance to the
future
Introductory greetings from
Pierluigi Gambetti
Case Western Reserve University,
USA pxg13@case.edu
presentation by Laura Cracco
Indiana University, USA
Session 4: Pathogenic Mechanisms (I) (Chairs: Chongsuk Ryou & Renshi Xu)
Keynote Speeches
David Harris
09:30 - 09:55 Prion neurotoxic pathways
Boston University, USA
daharris@bu.edu
Motohiro Horiuchi
09:55 - 10:20 Excitatory neuron tropism of prion propagation
Hokkaido University, Japan
horiuchi@vetmed.hokudai.ac.jp
Xiaoli Tian
10:20 - 10:45 Vascular aging and cognitive defect
Nanchang University, China
tianxiaoli@ncu.edu.cn
10:45 - 11:00 Coffee Break
11:00 - 11:25 Human prion diseases: Clinical variations & diagnosis
Richard Knight
University of Edinburgh, UK
r.knight@ed.ac.uk
11:25 - 11:50 Procrustean bed: Forcing PrPC into the PrPSc shape. A
perspective.
Jesús R. Requena
University of Santiago de
Compostela, Spain
jesus.requena@usc.es
Oral Presentations (selected from abstracts)
11:50 - 12:05
12:05 - 13:30 Time 13:30 - 14:30
14:30 - 14:55 14:55 - 15:20 15:20 - 15:45 15:45 - 16:00 16:00 - 16:15 16:15 - 16:40 Sup35N prion domain drives liquid-liquid phase
separation during hyperosmotic shock in a pH-
independent manner
Natalia Gorsheneva
St. Petersburg State University,
Russia
natalia.gorsheneva@mail.ru
Lunch
Plenary Speech (Chairs: Joaquín Castilla & Chao-Yang Li)
Title Speaker
Understanding the biology of prions and prion-like
misfolded protein aggregates in neurodegenerative
diseases
Claudio Soto
University of Texas Health Science
Center at Houston, USA
claudio.soto@uth.tmc.edu
Session 5: Pathogenic Mechanisms (II) (Chairs: Ilia V. Baskakov & Daojun Hong)
Keynote Speeches
Genetic modifiers of human prion diseases and potential
mechanisms
Simon Mead
University College London, UK
s.mead@prion.ucl.ac.uk
Rapid neurotoxicity in prion disease
Jiyan Ma
Chinese Institute for Brain
Research, China
majiyan@cibr.ac.cn
VPS35 regulation of the development and progression of
Alzheimer’s disease
Wencheng Xiong
Case Western Reserve University,
USA wxx119@case.edu
Coffee Break
Oral Presentations (selected from abstracts)
Cryo-correlative imaging of prion strains ex situ
Thomas J. Trainer
University College London, UK
t.trainer@prion.ucl.ac.uk
Session 6: Diagnostic Biomarkers (Chairs: Mark Zabel & Pingyi Xu)
Keynote Speeches
Sensitive detection of proteopathic seeds from surfaces,
tissue biopsies and biofluids
Christina Orrú
National Institutes of Health, USA
christina.orru@nih.gov
16:40 - 17:05 Structure-based design of a PET tracer of α-Synuclein
fibril for diagnosis of Parkinson's disease
Cong Liu
Shanghai Institute of Organic
Chemistry, CAS, China
liulab@sioc.ac.cn
17:05 - 17:30 Seeding activity of misfolded proteins in skin as
diagnostic biomarkers of neurodegenerative diseases
Wen-Quan Zou
The First Affiliated Hospital of
Nanchang University, China
wenquanzou@ncu.edu.cn
17:30 - 17:55 Brain organoid for modeling neural diseases
Nam-Hyung Kim
Wuyi University, China
nhkim@wyu.edu.cn
Oral Presentations (selected from abstracts)
17:55 - 18:10 Tubular-derived exosomal prion protein plays a critical
role in macrophage activation and renal fibrosis
Tantan Long
Nanfang Hospital, Southern
Medical University, China
zeishuailong@163.com
18:10 - 18:25 Anti-chaperone activity of prion disease risk factor
Syntaxin-6
Jan Bieschke
University College London, UK
j.bieschke@prion.ucl.ac.uk
18:25 - 19:30 Poster Session
19:30 - 21:00 Dinner
10/26/2024, Main Hall
Plenary Speech (Chairs: Cong Liu & Candace Mathiason)
Time Title Speaker
08:30 - 09:30 α-Synuclein and its involvement in neurodegenerative
diseases
Maria Grazia Spillantini
University of Cambridge, UK
mgs11@cam.ac.uk
Session 7: α-Synuclein in Prion & Prion-like Diseases (Chairs: Jian Wang & Hidehiro Mizusawa)
Keynote Speeches
09:30 - 09:55 Aberrant changes of the brain synuclein during prion
infection
Xiaoping Dong
CDC, China dongxp238@sina.com
09:55 - 10:20 Pathogenesis and early diagnosis of neurodegenerative
diseases
Keqiang Ye
Shenzhen Technology University,
China kq.ye@siat.ac.cn
10:20 - 10:35 Coffee Break
10:35 - 11:00 11:00 - 11:25 11:25 - 11:40 11:40 - 11:55
11:55 - 13:30 Time 13:30 - 14:30 14:30 - 14:55 14:55 - 15:20 15:20 - 15:35 15:35 - 16:00 The molecular interaction between α-Synuclein and
the prion protein and associated biological effects
Tiago Fleming Outeiro
University Medical Center
Göttingen, Germany
touteir@gwdg.de
Genetically modified large animal models of brain
diseases
Xiao-Jiang Li
Jinan University, China
xjli33w@jnu.edu.cn
Oral Presentations (selected from abstracts)
The role of α-Synuclein fuzzy coat in its transmission
activity
Zhuohao He
Shanghai Institute of Organic
Chemistry, CAS, China
hezh@sioc.ac.cn
A novel prion species identified in familial Creutzfeldt-
Jakob disease linked to substitution of glutamic acid
with Lysine at residue 200 of prion protein
Yue Lang
Case Western Reserve University,
USA langyue@jlu.edu.cn
Lunch
Plenary Speech (Chairs: Jiyan Ma & Jing Nie)
Title Speaker
Functional genomics of the prion life cycle
Adriano Aguzzi
University of Zurich, Switzerland
adriano.aguzzi@uzh.ch
Session 8: Aging and Neurodegenerative Diseases and Organoid Modeling
(Chairs: Emmanuel E. Comoy & Wei Luo)
Keynote Speeches
Prion mechanisms and aging: Lessons learned from
long-term experiments
Jean-Philippe Deslys
CEA-Prion Research Unit, France
jean-philippe.deslys@cea.fr
Prion evolution: The role of prion strain interference
Jason Bartz
Creighton University, USA
jbartz@creighton.edu
Coffee Break
Diagnostic value of skin biopsy RT-QuIC in prion
diseases
Liyong Wu
Xuanwu Hospital, Capital Medical
University, China
wmywly@hotmail.com
Oral Presentations (selected from abstracts)
16:00 - 16:15 Oral small molecules for reducing prion protein levels:
A new therapeutic strategy for prion disease
Nina Oberbeck
Gate Bioscience Inc., USA
noberbeck@gatebio.com
16:15 - 16:30 Genome-wide CRISPR activation screen identifies BMP
signaling pathway as mediator of prion uptake by cells
Elena De Cecco
University of Zurich, Switzerland
elena.dececco@usz.ch
Session 9: Animal Prion Diseases (Chairs: Ryan A. Maddox & Qi Shi)
Keynote Speeches
16:30 - 16:55 Developing vaccines for chronic wasting disease
Hermann Schatzel
University of Calgary, Canada
hschaetz@ucalgary.ca
16:55 - 17:20 Tracking longitudinal CWD shedding profiles in the
native host
Candace Mathiason
Colorado State University, USA
candace.mathiason@colostate.edu
Session 10: CJD international Support Alliance (Chairs: Xiaoping Dong & Christiane Stehmann)
17:20 - 17:40 Grants & fellowships: Empowering research. Inspiring
hope.
Maria Thacker Goethe
Georgia Bio, USA
mariathacker@gmail.com
17:40 - 18:00
CJD International Support Alliance (CJDISA) global
support for prion disease patients, their families and
those at risk
Suzanne Solvyns
CJD Support Group Network,
Australia
s.solvyns@cjdsupport.org.au
18:00 - 19:00 Poster Session
19:00 - 21:00 Dinner
10/27/2024, Main Hall
Plenary Session (Chairs: Christina Orrú & Jia-Yi Li)
Time Title Speaker
08:30 - 09:30 Self-propagating protein seeds as pathogens and
biomarkers
Byron Caughey
National Institutes of Health, USA
bcaughey@niaid.nih.gov
Session 11: Glial Cells in Neurodegenerative Diseases (Chairs: David Harris & Wencheng Xiong)
Keynote Speeches
Time Title Speaker
09:30 - 09:55 Reactive microglia envelop viable neurons in prion
diseases
Ilia V. Baskakov
University of Maryland, USA
baskakov@som.umaryland.edu
09:55 - 10:20 The impact of microglia-astrocyte cross-talk on CNS
prion disease pathogenesis
Neil Mabbott
University of Edinburgh, UK
neil.mabbott@roslin.ed.ac.uk
10:20 - 10:45
Peptide-addressed liposome-embedded therapeutic
systems: PALETS delivering tools to alter protein
expression and limit pathologic protein misfolding
Mark Zabel
Colorado State University, USA
mark.zabel@colostate.edu
10:45 - 11:00 Coffee Break
Session 12: Hot Topics, Breaking News & Controversies (Chairs: Simon Mead & Wen-Quan Zou)
11:00 - 11:15 Novel emergent CWD strains with unstable properties
cause chronic wasting disease (CWD) in Nordic cervids
Xutong Shi
Colorado State University, USA
xutong.shi@colostate.edu
11:15 – 11:30
Towards real-time monitoring of prion infection: Genetic
code expansion to enable site-specific bioorthogonal
labeling of functional and prion-convertible cellular
prion protein in live cells
Szymon W. Manka
University College London, UK
s.manka@ucl.ac.uk
11:30 - 11:45 Zoonotic potential of moose-derived chronic wasting
disease prions after adaptation in intermediate species
Tomás Barrio
École Nationale Vétérinaire de
Toulouse, France
tomas.barrio@envt.fr
Closing Session (Chairs: Jean-Philippe Deslys & Wen-Quan Zou)
11:45 - 12:30 Best Presentation, Poster Awards and Announcement of Prion 2025