Bing Sun, a NIH researcher and director of the Pasteur Institute in Shanghai, Chinese Academy of Sciences,was selected in the immunology major of the "Hundred Talents Program" of the Chinese Academy of Sciences.

 

• Sun Bing
• Researcher, research group leader, doctoral supervisor
• E-mail:  bsun@sibs.ac.cn

Personal profile:

He received his Ph.D. from Shanghai Second Medical University in 1991. From February 1994 to January 1999, he was engaged in postdoctoral and senior visiting scholar research at the National Institutes of Health (NIH), and from January 1999 to present in Biochemistry, Chinese Academy of Sciences With the Institute of Cell Biology, the Molecular Immunology Department was established, and he served as the research group leader and doctoral tutor. From April 2006 to December 2016, he was the director of the Pasteur Institute in Shanghai, Chinese Academy of Sciences.


　　Researcher Sun Bing has long been engaged in the research on the differentiation mechanism of T helper cells (Th), and explored the mechanism of action of different Th cell subsets in autoimmune diseases. He is currently a member of the American Association of Immunologists (AAI), the vice chairman of the Chinese Society of Immunology, and the executive director of the Chinese Society of Cellular Science. In 2003, he was awarded the support of the National Research Fund for Distinguished Young Scholars.


research direction:
Research on the differentiation mechanism of Th cells and their role in autoimmune diseases
research work:
　　1. Allergic Asthma


　　In recent years, due to air pollution (such as smog, etc.), the incidence of asthma has continued to rise, and the existing methods cannot be effectively controlled. Studies have shown that allergens can cause damage to lung mucosal epithelial cells, and further activate type II lymphoid immune cells (Innate lymphoid type 2 cells: ILC2) by releasing inflammatory cytokines such as IL-25, IL-33 and TSLP. ILC2 cells can secrete IL-5 and IL-13, and at the same time, under the action of allergens, they can drive naive CD4+ T cells to differentiate into Th2 cells, and finally induce asthma disease. The laboratory has been engaged in the research on the molecular mechanism of Allergic Asthma disease for a long time, and currently focuses on the function research and interaction regulation mechanism of Th2 and ILC2 two immune cells. Using a mouse model of allergic asthma, combined with clinical data from asthma patients, the study




How new transcriptional regulators, epigenetic molecules and metabolic signaling pathways and products regulate the functions of these cells and their regulatory mechanisms on the pathogenesis of asthma provide new ideas and strategies for the development of new drugs and the prevention and treatment of asthmatic diseases.
 


　　2. Cancer Immunotherapy


　　Since 2011, a variety of immune checkpoint blockers and targeted immune cell drugs have achieved good clinical results in the treatment of various tumors, and have developed into the most potential cancer treatment strategies currently recognized. The marketed immunotherapy methods only show good results in some patients, while drug resistance and poor prognosis appear in most tumor patients, which makes tumor immunotherapy have certain limitations. Relying on a mature mouse experimental system and patient samples provided by clinical hospitals, this study focused on exploring the important regulatory roles of CD8+ and Treg cells in the formation of Lung Cancer, and selected specific targets.




Use the laboratory's perfect single-cell technology to prepare antibodies and drug research and development technology systems, prepare tumor-targeted Treg and enhance the function of CD8+ cells, and then develop new antibodies with anti-tumor effects, evaluate the anti-tumor effects of new antibodies in vivo and in vitro, develop New drugs provide new regimens and strategies for antibody immunotherapy against Lung Cancer.
 


　　3. Antibody drug discovery


　　The laboratory has nearly 20 years of antibody research history, and has a complete antibody research platform. The laboratory has established a complete single-cell RT-PCR technology for the preparation of fully human monoclonal antibodies, especially for infectious diseases, which can quickly obtain therapeutic antibody drug candidates. At the same time, in response to the problem of immune tolerance in some antigen-immunized mice and the inability to obtain monoclonal antibodies, the immune tolerance can be broken by using the two mechanisms of somatic high-frequency mutation and somatic gene replacement in rabbit immune cells. The laboratory has established a technique for preparing rabbit monoclonal antibodies based on single-cell RT-PCR. Our technical system covers key steps in antibody drug development such as target discovery and validation, antibody preparation and functional evaluation, and intellectual property management. The laboratory has successfully developed and transformed projects such as HCV broad-spectrum neutralizing fully human antibodies. The laboratory is currently focusing on diseases such as asthma and tumors. Carry out basic and clinical research to develop innovative antibody drugs.


Representative works:
Chunyan Yi, Xiaoyu Sun , Jing Ye, Longfei Ding , Meiqin Liu , Zhuo Yang , Xiao Lu , Yaguang Zhang , Liyan Ma , Wangpeng Gu , Aidong Qu , Jianqing Xu , Zhengli Shi *, Zhiyang Ling* and Bing Sun *;Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cellular & Molecular Immunology , 2020, 17:621–630.
Yaguang Zhang, Xuezhen Li, Zhongguang Luo, Liyan Ma, Songling Zhu, Zhishuo Wang, Jing Wen, Shipeng Cheng, Wangpeng Gu, Qiaoshi Lian, Xinhao Zhao, Weiguo Fan, Zhiyang Ling, Jing Ye, Songguo Zheng, Dangsheng Li, Hongyan Wang , Jie Liu*, Bing Sun* ; ECM1 is an essential factor for the determination of M1macrophage polarization in IBD in response to LPS stimulation, PNAS, 2020, 117(6): 3083-3092.
Weiguo Fan, Tianhui Liu, Wen Chen, Seddik Hammad, Thomas Longerich, Ingrid Hausser, Yadong Fu, Nan Li, Yajing He, Cui Liu, Yaguang Zhang, Qiaoshi Lian, Xinhao Zhao, Chenghua Yan, Li Li, Chunyan Yi, Zhiyang Ling , Liyan Ma, Xinyan Zhao, Hufeng Xu, Ping Wang, Min Cong, Hong You, Zhihong Liu, Yan Wang, Jianfeng Chen, Dangsheng Li, Lijian Hui, Steven Dooley * , Jinlin Hou * , Jidong Jia * and Bing Sun * ( 2019). ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice. Gastroenterology. 2019;157:1352–1367.
Fang Yu*, Sharma Suveena, Dragana Jankovic, Rama Krishna Gurram, Pan Su, Gangqing Hu, Rao Li, Sadiye Rieder, Keji Zhao, Bing Sun *, Jinfang Zhu*; The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination, Journal of Experimental Medicine , 2018, 215(7): 1813-1821;
Lan He , Wangpeng Gu , Meng Wang , Xiaoyan Chang , Xiaoyu Sun , Yuan Zhang , Xuan Lin , Chenghua Yan , Weiguo Fan , Pan Su , Yanming Wang , Chunyan Yi , Guomei Lin , Li Li , Yu Jiang , Junxia Lu , Chen Dong , Haikun Wang, Bing Sun* . Extracellular Matrix Protein 1 promotes follicular helper T cells differentiation and antibody production. PNAS , 2018, 115(34): 8621-8626.
Qiaoshi Lian, Jun Xu, Shanshan Yan, Min Huang*, Honghua Ding, Xiaoyu Sun, Aiwei Bi, Jian Ding*, Bing Sun* , Meiyu Geng*, Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research , 2017, 27:784-800.
Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding &  Bing Sun* . Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature Communications,  2016; 7: 13577 
Su Pan, Chen Sheng, Zheng Yuhan, Zhou Haiyan, Yan CH, Yu F, Zhang YG, He L, Zhang Y, Wang YM, Wu L, Wu XA, Yu BK, Ma LY, Yang ZR, Wang JH, Zhao GX , Zhu JF, Wu ZY,  Sun B* . Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. Journal of Immunology  2016; 197(4): 1054-1064. 
Wang Yanming, Lian QS, Yang B, Yan SS, Zhou HY, He L, Lin GM, Lian ZX, Jiang ZF,  Sun B* . TRIM30 alpha Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. Plos Pathogens . 2015;11(6):18. 
Sha Wenwen, Mitoma H, Hanabuchi S, Bao MS, Weng LY, Sugimoto N, Liu Y, Zhang ZQ, Zhong J,  Sun B* , Liu YJ*. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. PNAS. 2014; 111 (45): 16059-16064.  
OuYang Bo, Xie SQ, Berardi MJ, Zhao XH, Dev J, Yu WJ,  Sun B* , Chou JJ*. Unusual architecture of the p7 channel from hepatitis C virus.  Nature  . 2013; 498(7455):521.
Mao Kairui, Chen SZ, Chen MK, Ma YL, Wang Y, Huang B, He ZY, Zeng Y, Hu Y, Sun SH, Li J, Wu XD, Wang XR, Strober W, Chen C, MengGX,  Sun B* . Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.  Cell Research  . 2013; 23(2):201-212.
Zhenhu Li, Yuan Zhang, Zhiduo Liu, Xiaodong Wu, Yuhan Zheng, Zhiyun Tao, Kairui Mao, Jie Wang, Guomei Lin, Lin Tian, ​​Yongyong Ji, Meiling Qin, Shuhui Sun, Xueliang Zhu, and  Bing Sun* . Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1. Nature Immunology.  2011; 12(2):178-85 
Zhiduo Liu, Zhenhu Li, Kairui Mao, Jia Zou, Yuan Wang, Zhiyun Tao, Guomei Lin, Lin Tian, ​​Yongyong Ji, Xiaodong Wu, Xueliang Zhu, Shuhui Sun, Weiguang Chen, Charlie Xiang and  Bing Sun*. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.  Journal of Immunology . 2009;183(10):6320-9
Xuexian O Yang, Pornpimon Angkasekwinai, Jinfang Zhu, Juan Peng, Zhiduo Liu, Roza Nurieva, Xikui Liu, Yeonseok Chung, Seon Hee Chang,  Bing Sun* , Chen Dong*. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.  Nature Immunology . 2009;10(12):1260-6
Mude Shi, Weiwen Deng, Enguang Bi, Kairui Mao, Yongyong Ji, Guomei Lin, Xiaodong Wu, Zhiyun Tao, Zhenhu Li, Xinfen Cai, Shuhui Sun, Charlie Xiang and  Bing Sun*. TRIM30a negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation. Nature Immunology . 2008;9(4):369-77. 
Wei Lu, Bojian Zheng, Ke Xu, Wolfgang Schwarz, Jiadong Cheng, Shuming Duan, Vincent Deubel,  Bing Sun * . SARS-CoV 3a protein forms an ion channel and modulates virus release.  PNAS.  2006; 103(33);12540- 12545.

Sun Bing received his PhD in Immunology from Shanghai Second Medical University in January 1991. From January 1991 to January 1994, he was a lecturer and associate professor at Shanghai Medical University. From February 1994 to January 1999, he was a postdoctoral fellow and senior visiting scholar at NIH in the United States. In 1998, he was selected as the immunology major of the "Hundred Talents Program" of the Chinese Academy of Sciences. Since February 1999, he has been in charge of basic immunology research at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. In 2003, he was awarded the title of National Outstanding Youth and supported by the Research Fund. Since 2003, he has been a member of the Review Committee of the Immunology Professional Group of the National Natural Science Foundation of China. Since January 2005, he has been the director of the Antibody Research Center of the Institute of Biochemical Cells, Shanghai Academy of Biological Sciences, Chinese Academy of Sciences. He is currently the co-director of the Pasteur Institute in Shanghai, Chinese Academy of Sciences.

Published papers and scientific research:

He has presided over and participated in the innovation projects of the Chinese Academy of Sciences, the general and key projects of the National Natural Science Foundation of China, the National 973 Project, the key and major projects of the Shanghai Science and Technology Commission, and the Sino-German cooperation project, and participated in the Shanghai Science and Technology Commission and the Natural Science Foundation of China. and the excellent talent research team of the Chinese Academy of Sciences. He is an adjunct professor at the School of Life Sciences of the University of Science and Technology of China and the School of Medicine of Shanghai Jiaotong University. There are 15 doctoral and 10 master students. After returning to China, as the corresponding author, he has published nearly 20 SCI articles.