Xiao Su, a researcher at the Pasteur Institute of Shanghai, Chinese Academy of Sciences, the winner of the 100 Talents Program of CAS,was postdoctoral fellow at UCSF, Assistant Research Professor at UIC and Associate Researcher at UCSF and received the American NIH Ruth L. Kirschstein Award

 Research team leader

Name:	Su Xiao	gender:	male
Education:	PhD
Expert Category:		job title:	researcher
Department:	Respiratory Infection Immunity Research Group	Subject Category:	Pulmonary infection immune neuromodulation
contact number:	021-54923111	E-mail:	xsu@ips.ac.cn
mailing address:	New Life Science Research Building, No. 320, Yueyang Road, Xuhui District, Shanghai

Personal profile:

Su Xiao, Ph.D., researcher, doctoral supervisor, winner of the Hundred Talents Program of the Chinese Academy of Sciences. Fudan University and U.S. UCSF jointly cultivate Ph.D. , U.S. UCSF postdoctoral fellow , U.S. UIC assistant research professor and UCSF associate researcher. Since 2012 , he has been the director of the Respiratory Infection and Immunity Laboratory of the Pasteur Institute in Shanghai. He presided over 2 key projects of the National Natural Science Foundation of China , 4 general projects of the National Natural Science Foundation of China, and basic key projects of Shanghai; participated in the national key research and development plan and the pilot B project of the Chinese Academy of Sciences. Served as a first- and second-instance expert for outstanding young, major, key and general projects of the National Natural Science Foundation of China; a first- and second-instance expert for the National Key R&D Program; an evaluation expert for the Hong Kong Science Foundation. Participated in the formulation of the 13th and 14th five-year strategic plans for the respiratory field of the National Natural Science Foundation of China. Deputy Editor-in-Chief of QJM Magazine , Oxford University Press , Deputy Editor-in-Chief of Frontiers in Medicine , and reviewer and reviewer of various SCI journals. Published 80 papers, including in Nature Med , Lancet , JCI, Journal of Immunolgy , Cell Discovery , Cell Death & Diseases and other more than 40 SCI papers , 30 corresponding (co) authors , and the citation rate of the paper is > 3300 times. He has won the Parker B. Francis Lung Biomedical Award in the United States, the NIH Ruth L. Kirschstein Award in the United States, the Guanghua Award of Fudan University, and the first prize of the Municipal Science and Technology Progress Award.

research direction:

It has opened up the field of vagus nerve regulation of pulmonary infection immunity. The theory of pulmonary parasympathetic inflammatory reflex arc is proposed to explain the molecular mechanism of the nervous system's recognition of respiratory tract infections and pathogens, and the immune regulation of neuropeptides on pulmonary infections (Huang, et al. QJM. 2018) . found that activation of α7 nAChR in monocytes / macrophages can epigenetically modify histone deacetylation and NF-kB p65 activity, inhibit the transcription of inflammatory cytokines, and induce anti-inflammatory memory in inflammatory cells ( Yang, et al. QJM .2017 ). It was found that the vagus nerve promotes AKT1 phosphorylation in α 7 nAChR+CD11b+ cells , inhibits spleen inflammatory cell mobilization and lung recruitment, and alleviates the molecular mechanism of E. coli and LPS -induced acute lung injury ( Zhao, et al. Cell Discovery. 2017 ). Knockdown of α7 nAChR was found to significantly inhibit bleomycin-induced pulmonary fibrosis ( Sun, et al. Mol Med. 2017 ). Discovered a new mechanism by which RSV breaks asthma tolerance ( Shi, et al. Mol Immunol. 2017 ). Discovered the molecular mechanism of granulocyte HIF-1α regulating LPS/E.coli -induced acute lung injury (Huang, et al. QJM. 2018 ). Discovered the molecular mechanism of vagus nerve regulating influenza virus replication in lung epithelial cells and regulation of macrophage II polarization through α 7 nAChR ; discovered the mechanism of vagus nerve regulating stem cells through α 7 nAChR ; found that lung epithelial cells and granulocytes SOCS3 in influenza virus infection The role of Akt1/2 in regulation of Tfh development; the discovery of the molecular mechanism of stem cell cGAS recognition of dsDNA affecting the repair of lung infection ; the discovery of the molecular mechanism of neural regulation of ZIKV infection. Recently, it was found that HIF1a in lung epithelial cells can regulate influenza virus replication ( EMI ) by affecting autophagy ; molecular mechanism of pyroptosis ( CDD ) of mesenchymal stem cells; molecular mechanism of vagus nerve regulation of asthma tolerance ( AJP ), etc. Basic Information 　　 　 　 Name: Su Xiao  gender: male Education: PhD Expert Category: Immunology job title: researcher Subject group name: Respiratory Infection Immunity Research Group Subject Category: Immunology contact number: 021-54923110 E-mail: xsu@ips.ac.cn mailing address: Pasteur Institute, No. 320, Yueyang Road, Shanghai Educational background (Education) 2004-2007  Postdoc at University of California, San Francisco 2002-2004 Ph.D., Fudan University (joint training with UCSF) 1988-1991 Master of Medicine, Soochow University Employment History 2012.08-present Researcher, Institut Pasteur, Shanghai, Chinese Academy of Sciences 2011.07-2012.08 Associate Research Fellow, Department of Anesthesiology, University of California, San Francisco 2009.10-2011.06 Research Assistant, Cardiovascular Research Institute, University of California, San Francisco 2007.11-2009.09 Research Assistant Professor, Department of Pharmacy, University of Illinois at Chicago 1991.08-2000.08 Director of the Department of Critical Care Medicine, Kailuan Hospital Affiliated to North China Coal Medical College Membership In Professional Societies 2013 to present Deputy Editor-in-Chief of QJM 2013 to present PLOS ONE Academic Editor-in-Chief from 2012 to present National Natural Science Foundation of China outstanding youth, major, key, general, youth projects, evaluation experts or guidance experts of national key research and development plans Honors and Awards 2001 Guanghua Award of Fudan University 2008 Parker B. Francis Award 2007 NIH Ruth L. Kirschstein Award

Yuan Gao, a former researcher at NIH and NIST in the US, was recruited to the " Hundred Talents Program " of the Chinese Academy of Sciences as researcher of Chinese National Nanoscience Center

 

Gao Yuan, researcher, doctoral supervisor of Chinese National Nanoscience Center. In 2005 and 2011 , he obtained his bachelor's degree and doctor's degree from Nanjing University Intensive Department ( DII ) and Brandeis University, respectively. From 2011 to 2013 , he was a postdoctoral fellow at Brandeis University, and his supervisor was Professor Xu Bing. 2013-2015 Research Associate at the National Institutes of Health (NIH ) and National Institute of Standards and Technology ( NIST ) . He has been engaged in the research of supramolecular self-assembly and biological nanomaterials for a long time. Published more than 60 papers, including Nat. Commun., JACS, Adv. Mater., Chem. Soc. Rev. , etc., cited more than 4900 times. Obtained a US patent grant.

   Research group website : http://www.nanoctr.cas.cn/yuangao/

Research areas:

 

  In vivo supramolecular assembly methodology

  Dynamic allostery of supramolecular assemblies

  Drug Delivery and Bioorthogonal Prodrugs

  Dynamic Light Scattering Small Angle Neutron Scattering 

 Awards and Honors:

   

 Representative works:

 

1.        Gao, Y. ; Kuang, Y.; Guo, Z.-F.; Guo, ZH; Krauss, IJ; Xu, B.* “Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and A Supramolecular Hydrogel of Taxol Derivative "  J. Am. Chem. Soc. ,  2009 ,  131 , 13576-13577 ."

2.        Gao, Y. ; Zhao, F.; Wang, L.; Zhang, Y.; Xu, B.* “Small Peptide Nanofibers as the Matrices of Molecular Hydrogels for Mimicking Enzymes and Enhancing the Activity of Enzymes”  Chem. Soc .  Rev. 2010,  39 , 3425-3433.

3.        Gao, Y. ; Shi, JF; Yuan, D.; Xu, B.* “Imaging enzyme-triggered self-assembly of small molecules inside live cells” Nat. Commun ., 2012 , 3 , 1033.

4.       Huang, P.*, Gao, Y.* , Lin, J., Hu, H., Liao, H., Yan, X., Tang, Y., Jin, A., Song, J., Niu , G., Zhang, G., Horkay, F., Chen, X.* “Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics” ACS Nano ,  2015 ,  9 , 9517–9527.

5.       Liu, Y., Qu, Z., Cao, H., Sun, H., Gao, Y. * , Jiang, X.* “pH Switchable Nano-Assembly for Imaging A Broad Range of Malignant Tumors” ACS Nano , 2017 , 11 , 12446? 12452.

6.       Yao, Q., Lin, F., Fan, X., Wang, Y., Liu, Y., Liu, Z., Jiang, X., Chen, P.*, Gao, Y.* “Synergistic Enzymatic and Bioorthogonal Reactions for Selective Prodrug Activation in Living Systems” Nat. Commun., 2018 , 9 , 5032.

7.       Yao, Q., Huang, Z., Liu, D., Chen, J., Gao, Y. * “Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity” Adv. Mater. , 2019 , 31 , 1804814.

8.       Yao, Q.#, Wang, C.#, Fu, M., Dai, L.*, Li, J.*, Gao, Y.* “Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super- Resolution Microscopy.” ACS Nano , 2020 , 14 , 4882-4889.

9.       Huang, Z.#, Liu, Y.#, Wang, L., Ali, A., Yao, Q., Jiang, X.*, Gao, Y.* “Supramolecular Assemblies mimicking Neutrophil Extracellular Traps for MRSE Infection Control.” Biomaterials , 2020 , 253 , 120124.

10.   Yao, Q., Gao, S., Wu, C., Lin, T.*, Gao, Y.* “Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance” . Biomaterials , 2021 , 277 , 121119.

The National Nanoscience Center is a fully funded institution jointly established by the Chinese Academy of Sciences and the Ministry of Education and has an independent legal personality. According to the needs of scientific research work, the research group of Gao Yuan (researcher of the " Hundred Talents Program " of the Chinese Academy of Sciences ) of the Nanomaterials Research Office is looking for associate researchers, assistant researchers, postdoctoral fellows and project employees. Our group is mainly engaged in the research of biological nanomaterials, including supramolecular self-assembly, molecular imaging, cancer diagnosis and treatment, etc.

1. Research direction

1. Synthesis and preparation of biocompatible nanomaterials (including small organic molecules, polymers and inorganic nanoparticles);

2. Research on supramolecular self-assembly in response to biological environment and its biological effects;

3. Drug control and release based on nanomaterials;

4. Optimize cancer diagnosis and treatment (precision medicine).

2. Application conditions

1 . associate researcher, assistant researcher

Possess a doctorate degree in related fields such as organic synthesis, molecular imaging, chemical biology, molecular biology, etc.;

Have independent scientific research ability and have published many high-level professional papers as the first author;

Those with fund application experience or overseas experience are preferred.

2 . postdoc

Possess a doctorate degree in related fields such as organic synthesis, molecular imaging, chemical biology, molecular biology, etc.;

Have independent scientific research ability and have published high-level professional papers as the first author;

3 . Project employment (research assistant)

Have a master's degree or above in biology, chemical biology, or molecular biology or other related professional background;

Have good scientific research literacy, scientific research training and teamwork spirit; have strong language expression and communication skills;

Assist the research group in scientific research management and internal daily affairs.

3. Benefits

Salary and benefits are implemented in accordance with the relevant regulations of the National Nanoscience Center.

4. Application method

Interested applicants please send your resume, job application form , information brief and relevant materials that can reflect your personal abilities to gaoy@nanctr.cn (copy to dhr@nanctr.cn ), please be sure to note in the subject of the email Ming apply for the research group and position .

5. Contact information

Mailing address: National Nanoscience Center, No. 11 , North One, Zhongguancun, Haidian District, Beijing

Postcode: 100190