| Name: | Su Xiao | gender: | male |
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| Education: | PhD | ||
| Expert Category: | job title: | researcher | |
| Department: | Respiratory Infection Immunity Research Group | Subject Category: | Pulmonary infection immune neuromodulation |
| contact number: | 021-54923111 | E-mail: | xsu@ips.ac.cn |
| mailing address: | New Life Science Research Building, No. 320, Yueyang Road, Xuhui District, Shanghai | ||
| Personal profile: |
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Su Xiao, Ph.D., researcher, doctoral supervisor, winner of the Hundred Talents Program of the Chinese Academy of Sciences. Fudan University and U.S. UCSF jointly cultivate Ph.D. , U.S. UCSF postdoctoral fellow , U.S. UIC assistant research professor and UCSF associate researcher. Since 2012 , he has been the director of the Respiratory Infection and Immunity Laboratory of the Pasteur Institute in Shanghai. He presided over 2 key projects of the National Natural Science Foundation of China , 4 general projects of the National Natural Science Foundation of China, and basic key projects of Shanghai; participated in the national key research and development plan and the pilot B project of the Chinese Academy of Sciences. Served as a first- and second-instance expert for outstanding young, major, key and general projects of the National Natural Science Foundation of China; a first- and second-instance expert for the National Key R&D Program; an evaluation expert for the Hong Kong Science Foundation. Participated in the formulation of the 13th and 14th five-year strategic plans for the respiratory field of the National Natural Science Foundation of China. Deputy Editor-in-Chief of QJM Magazine , Oxford University Press , Deputy Editor-in-Chief of Frontiers in Medicine , and reviewer and reviewer of various SCI journals. Published 80 papers, including in Nature Med , Lancet , JCI, Journal of Immunolgy , Cell Discovery , Cell Death & Diseases and other more than 40 SCI papers , 30 corresponding (co) authors , and the citation rate of the paper is > 3300 times. He has won the Parker B. Francis Lung Biomedical Award in the United States, the NIH Ruth L. Kirschstein Award in the United States, the Guanghua Award of Fudan University, and the first prize of the Municipal Science and Technology Progress Award. |
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It has opened up the field of vagus nerve regulation of pulmonary infection immunity. The theory of pulmonary parasympathetic inflammatory reflex arc is proposed to explain the molecular mechanism of the nervous system's recognition of respiratory tract infections and pathogens, and the immune regulation of neuropeptides on pulmonary infections (Huang, et al. QJM. 2018) . found that activation of α7 nAChR in monocytes / macrophages can epigenetically modify histone deacetylation and NF-kB p65 activity, inhibit the transcription of inflammatory cytokines, and induce anti-inflammatory memory in inflammatory cells ( Yang, et al. QJM .2017 ). It was found that the vagus nerve promotes AKT1 phosphorylation in α 7 nAChR+CD11b+ cells , inhibits spleen inflammatory cell mobilization and lung recruitment, and alleviates the molecular mechanism of E. coli and LPS -induced acute lung injury ( Zhao, et al. Cell Discovery. 2017 ). Knockdown of α7 nAChR was found to significantly inhibit bleomycin-induced pulmonary fibrosis ( Sun, et al. Mol Med. 2017 ). Discovered a new mechanism by which RSV breaks asthma tolerance ( Shi, et al. Mol Immunol. 2017 ). Discovered the molecular mechanism of granulocyte HIF-1α regulating LPS/E.coli -induced acute lung injury (Huang, et al. QJM. 2018 ). Discovered the molecular mechanism of vagus nerve regulating influenza virus replication in lung epithelial cells and regulation of macrophage II polarization through α 7 nAChR ; discovered the mechanism of vagus nerve regulating stem cells through α 7 nAChR ; found that lung epithelial cells and granulocytes SOCS3 in influenza virus infection The role of Akt1/2 in regulation of Tfh development; the discovery of the molecular mechanism of stem cell cGAS recognition of dsDNA affecting the repair of lung infection ; the discovery of the molecular mechanism of neural regulation of ZIKV infection. Recently, it was found that HIF1a in lung epithelial cells can regulate influenza virus replication ( EMI ) by affecting autophagy ; molecular mechanism of pyroptosis ( CDD ) of mesenchymal stem cells; molecular mechanism of vagus nerve regulation of asthma tolerance ( AJP ), etc.
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