Gao Yuan, researcher, doctoral supervisor of Chinese National Nanoscience Center. In 2005 and 2011 , he obtained his bachelor's degree and doctor's degree from Nanjing University Intensive Department ( DII ) and Brandeis University, respectively. From 2011 to 2013 , he was a postdoctoral fellow at Brandeis University, and his supervisor was Professor Xu Bing. 2013-2015 Research Associate at the National Institutes of Health (NIH ) and National Institute of Standards and Technology ( NIST ) . He has been engaged in the research of supramolecular self-assembly and biological nanomaterials for a long time. Published more than 60 papers, including Nat. Commun., JACS, Adv. Mater., Chem. Soc. Rev. , etc., cited more than 4900 times. Obtained a US patent grant.
Research group website : http://www.nanoctr.cas.cn/yuangao/
Research areas:
In vivo supramolecular assembly methodology
Dynamic allostery of supramolecular assemblies
Drug Delivery and Bioorthogonal Prodrugs
Dynamic Light Scattering Small Angle Neutron Scattering
Awards and Honors:
Representative works:
1. Gao, Y. ; Kuang, Y.; Guo, Z.-F.; Guo, ZH; Krauss, IJ; Xu, B.* “Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and A Supramolecular Hydrogel of Taxol Derivative " J. Am. Chem. Soc. , 2009 , 131 , 13576-13577 ."
2. Gao, Y. ; Zhao, F.; Wang, L.; Zhang, Y.; Xu, B.* “Small Peptide Nanofibers as the Matrices of Molecular Hydrogels for Mimicking Enzymes and Enhancing the Activity of Enzymes” Chem. Soc . Rev. 2010, 39 , 3425-3433.
3. Gao, Y. ; Shi, JF; Yuan, D.; Xu, B.* “Imaging enzyme-triggered self-assembly of small molecules inside live cells” Nat. Commun ., 2012 , 3 , 1033.
4. Huang, P.*, Gao, Y.* , Lin, J., Hu, H., Liao, H., Yan, X., Tang, Y., Jin, A., Song, J., Niu , G., Zhang, G., Horkay, F., Chen, X.* “Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics” ACS Nano , 2015 , 9 , 9517–9527.
5. Liu, Y., Qu, Z., Cao, H., Sun, H., Gao, Y. * , Jiang, X.* “pH Switchable Nano-Assembly for Imaging A Broad Range of Malignant Tumors” ACS Nano , 2017 , 11 , 12446? 12452.
6. Yao, Q., Lin, F., Fan, X., Wang, Y., Liu, Y., Liu, Z., Jiang, X., Chen, P.*, Gao, Y.* “Synergistic Enzymatic and Bioorthogonal Reactions for Selective Prodrug Activation in Living Systems” Nat. Commun., 2018 , 9 , 5032.
7. Yao, Q., Huang, Z., Liu, D., Chen, J., Gao, Y. * “Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity” Adv. Mater. , 2019 , 31 , 1804814.
8. Yao, Q.#, Wang, C.#, Fu, M., Dai, L.*, Li, J.*, Gao, Y.* “Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super- Resolution Microscopy.” ACS Nano , 2020 , 14 , 4882-4889.
9. Huang, Z.#, Liu, Y.#, Wang, L., Ali, A., Yao, Q., Jiang, X.*, Gao, Y.* “Supramolecular Assemblies mimicking Neutrophil Extracellular Traps for MRSE Infection Control.” Biomaterials , 2020 , 253 , 120124.
10. Yao, Q., Gao, S., Wu, C., Lin, T.*, Gao, Y.* “Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance” . Biomaterials , 2021 , 277 , 121119.
The National Nanoscience Center is a fully funded institution jointly established by the Chinese Academy of Sciences and the Ministry of Education and has an independent legal personality. According to the needs of scientific research work, the research group of Gao Yuan (researcher of the " Hundred Talents Program " of the Chinese Academy of Sciences ) of the Nanomaterials Research Office is looking for associate researchers, assistant researchers, postdoctoral fellows and project employees. Our group is mainly engaged in the research of biological nanomaterials, including supramolecular self-assembly, molecular imaging, cancer diagnosis and treatment, etc.
1. Research direction
1. Synthesis and preparation of biocompatible nanomaterials (including small organic molecules, polymers and inorganic nanoparticles);
2. Research on supramolecular self-assembly in response to biological environment and its biological effects;
3. Drug control and release based on nanomaterials;
4. Optimize cancer diagnosis and treatment (precision medicine).
2. Application conditions
1 . associate researcher, assistant researcher
Possess a doctorate degree in related fields such as organic synthesis, molecular imaging, chemical biology, molecular biology, etc.;
Have independent scientific research ability and have published many high-level professional papers as the first author;
Those with fund application experience or overseas experience are preferred.
2 . postdoc
Possess a doctorate degree in related fields such as organic synthesis, molecular imaging, chemical biology, molecular biology, etc.;
Have independent scientific research ability and have published high-level professional papers as the first author;
3 . Project employment (research assistant)
Have a master's degree or above in biology, chemical biology, or molecular biology or other related professional background;
Have good scientific research literacy, scientific research training and teamwork spirit; have strong language expression and communication skills;
Assist the research group in scientific research management and internal daily affairs.
3. Benefits
Salary and benefits are implemented in accordance with the relevant regulations of the National Nanoscience Center.
4. Application method
Interested applicants please send your resume, job application form , information brief and relevant materials that can reflect your personal abilities to gaoy@nanctr.cn (copy to dhr@nanctr.cn ), please be sure to note in the subject of the email Ming apply for the research group and position .
5. Contact information
Mailing address: National Nanoscience Center, No. 11 , North One, Zhongguancun, Haidian District, Beijing
Postcode: 100190
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