 | Xu ZhihengTitle: Researcher Tel: 86-10-64806581 (O) E-mail： zhxu@genetics.ac.cn Research direction: signal transduction and the pathophysiological mechanism of disease |
Xu Zhiheng, Ph.D., researcher, doctoral supervisor
, graduated from Shanghai Second Military Medical University in 1989, and received his Ph.D. from Rutgers University, New Jersey, USA in 1999. From 1999 to 2005, he worked as a postdoctoral fellow and senior research assistant at Columbia University, USA. Published more than 60 papers as corresponding authors, including Science, Cell Stem Cell, Nature Neuroscience, Immunity, Nature Metabolism, Nature Communications (3 papers), Cell Reports (5 papers), Cell Research (4 papers), Blood, Hepatology, Advanced Science , PNAS, J Cell Biol., PLoS Biology, Annual Review Virology, MCB (2 articles), JBC (6 articles) and other world-class journals. He has successively received Ruth L. Kirschstein National Research Service Award from NIH, Bush Fellowship and Waksman Fellowship of Rutgers University, National Science Fund for Distinguished Young Scholars, Innovation Group (Principal) of the Fund Committee, and 863 Project (Chief) funding. As well as "2019 and 2021 Chinese Academy of Sciences Outstanding Mentor Award", "Tang Lixin Teaching Famous Teacher Award", "Zhu Liyuehua Outstanding Teacher Award" and "Yihai Kerry Outstanding Teacher Award", and the first prize of Beijing Science and Technology Award.
Main research contents:
1) Combined analysis of bioinformatics and multi-omics (single-cell sequencing, ATAC sequencing, genome, proteome, lipid metabolome, etc.), high-resolution imaging, in vivo labeling and imaging, neural lineage and Neural circuit tracing, optical and chemical genetics, and the intersection of the above-mentioned multidisciplinary techniques and molecular and cellular biology techniques, in-depth study of the molecular and cellular mechanisms of brain development.
2) Discover new pathogenic genes, establish and use genetic manipulation mouse models to study the pathogenesis of neuropsychiatric diseases such as microcephaly, autism, schizophrenia, ALS and multiple sclerosis.
Student Awards (2012-19):
"Excellent Doctoral Dissertation of Chinese Academy of Sciences" (2 persons); "Chinese Academy of Sciences President's Award" (4 persons); "Chinese Society of Cell Biology Outstanding Young Papers" first prize (highest level, 2 persons); "Zhang Xiangtong Outstanding Neuroscience Award" "Thesis Award"; "UCAS-BHP Billiton Scholarship"; "Li Zhensheng Scholarship" (3 persons); "Procter & Gamble Outstanding Graduate Student Award of University of Chinese Academy of Sciences"; "Hengyuanxiang Talent Award" (3 persons); "Yihai Kerry Outstanding Doctoral Student Award" " (4 people); "Diao Scholarship" first prize (2 people), etc. A doctoral student was directly employed by Xiangya Medical College of Central South University (985 University) as a distinguished professor and doctoral supervisor. Another doctoral student was hired by Fujian University (now Fujian Medical University) as a Distinguished Associate Professor (Independent Researcher).
PUBLICATIONS (* Corresponding author)
1.Pang HH, Jiang YS… Xu Z*, Hu ZP* (2021) Aberrant NAD+ metabolism underlies ZIKA virus-induced microcephaly Nature Metabolism Doi: 10.1038/s42255-021-00437-0
2.Chang YF, Jiang YS, et al., Xu Z* (2021) Dissecting of the Gene Networks Affected by Zika Virus Infection in a Mouse Microcephaly Model. Genomics Proteomics & Bioinformatics doi.org/10.1016/j.gpb.2019.06.004 (IF:7.3)
3.Li C, Zheng Y, et al., Xu Z* (2021) SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development. Cell Death & Disease. 12;12(1):75. doi: 10.1038/s41419-020-03363-3. (IF: 6.3)
4. Xin Tai Wang, Lin Zhou, Xinyu Cai, Fangxiao Xu, Zhiheng Xu , Xiang-Yao LI, Ying Shen (2021) Deletion of Mea6 in cerebellar granule cells impairs synaptic development and motor performance. Frontiers in Cell and Developmental Biology doi. org/10.3389/fcell.2020.627146
5.Li C*, Xu D, Xu Z* (2021) The development of human antibodies against Zika virus. Zika Virus Control, Vaccines, Therapy, and Associated Conditions. Elsevier (book chapter)
6.Xu D*, Li C, Xu Z*(2021) Zika virus infection disrupts the development of both neurons and glial cells. Zika Virus Biology, Transmission, and Pathology. Elsevier (book chapter)
7.Zhao Z et al.,…Zhang XH*, Xu Z*(2020) Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science DOI:10.1002/advs.201901996 (IF:15.8)
8.Shohayeb B, Ho U, Yeap YY, Parton RG, Millard SS, Xu Z, Piper M, Ng DCH. (2020)The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. HUMAN MOLECULAR GENETICS，2020,29(2):248-263,
9.Zhang M, Fu Z, Li C, Liu A, Peng D, Xue F, He W, Gao S, Xu F, Xu D, Yuan L, Zhang F, Xu Z, Xu T, Xu P. Fast Super-Resolution Imaging Technique and Immediate Early Nanostructure Capturing by a Photoconvertible Fluorescent Protein. Nano Lett. 2020 Apr 8;20(4):2197-2208
10. Wang J, Li T, Wang JL, Xu Z, Meng W, Wu QF. (2020) Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. Cell Rep. 15;33(11):108495. doi: 10.1016/j.celrep.2020.108495.
11. Xu D, Li C, Qin CF, Xu Z*(2019) Update on the Animal Models and Underlying Mechanisms for ZIKV-Induced Microcephaly. Annu. Rev. Virol. doi.org/10.1146/annurev-virology-092818-015740
12. Nielsen-Saines K, Brasil P, Kerin T, Vasconcelos Z, Gabaglia CR, Damasceno L, Pone M, Abreu de Carvalho LM, Pone SM, Zin AA, Tsui I, Salles TRS, da Cunha DC, Costa RP, Malacarne J, Reis AB, Hasue RH, Aizawa CYP, Genovesi FF, Einspieler C, Marschik PB, Pereira JP, Gaw SL, Adachi K, Cherry JD, Xu Z, Cheng G, Moreira ME. (2019) Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children. Nat Med. 25(8):1213-1217. doi: 10.1038/s41591-019-0496-1
13. Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG. (2019).Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 20;101(6):1089-1098.e4. doi: 10.1016/j.neuron.2019.01.010.
14. Wang XT et al., Xu Z*, Shen Y* (2019) MEA6 deficiency impairs cerebellar development and motor performance by tethering protein trafficking. Frontiers in Cellular Neuroscience 11;13:250. doi: 10.3389/fncel.2019.00250
15. Xu YP, Qiu Y, Zhang B, Chen G, Chen Q, Wang M, Mo F, Xu J, Wu J, Zhang RR, Cheng ML, Zhang NN, Lyu B, Zhu WL, Wu MH, Ye Q, Zhang D, Man JH, Li XF, Cui J, Xu Z, Hu B, Zhou X, Qin CF. (2019) Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. Cell Res. 2019 Apr;29(4):265-273. doi: 10.1038/s41422-019-0152-9.
16. "Zika Virus and Zika Virus Disease" Chapter 10 Xu Dan, Xu Zhiheng Zika Virus and Zika Virus Disease. (2019) People's Health Publishing House
17. Wang S. et al., Xu Z* . (2018). Sh3rf2 haploinsufficiency leads to unilateral neuronal development deficits and autistic-like behaviors in mice. Cell Reports DOI: 10.1016/j.celrep.2018.11.044 (Xinhua and China Science News conducted an interview report)
18. Zhang et al., Xu Z* (2018) cTAGE5/MEA6 Controls Brain Development through Regulation of Neuronal Trafficking of Cellular Components. PNAS doi/10.1073/pnas.1804083115
(Direct Submission Plus)
19. Xu D., Zhu Y., and Xu Z*. (2018) MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis. PLoS Biology 19;16(12):e2006613. doi: 10.1371/journal.pbio.2006613
20. Li C et al., Xu Z*, Zhang L*. (2018). A single injection of human neutralizing antibody protects against Zika virus infection and microcephaly in the developing fetuses. Cell Reports DOI: 10.1016/j.celrep.2018.04.005
21. Li C et al., Xu Z*. (2018). Disruption of Glial Cell Development by Zika Virus Contributes to Severe Microcephalic Newborn Mice. Cell Discovery DOI: 10.1038/s41421-018-0042-1.
22. Zhu X, Li C, Afridi SK, Zu S, Xu JW, Quanquin N, Yang H, Cheng G*, Xu Z*. (2018). E90 subunit vaccine protects mice from Zika virus infection and microcephaly. Acta Neuropathol Commun. 2018 Aug 10;6(1):77. doi: 10.1186/s40478-018-0572-7. (IF: 5.4)
23. Zhou Y... Xu Z*, Chen ZJ*, Gao F*. (2018). Wdr62 is involved in meiotic initiation via activating JNK signaling and associated with POI in humans. PLoS Genet. 13;14(8):e1007463. doi: 10.1371/journal.pgen.1007463.
24. Zhang H...Xu Z, Sun T. (2018). Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice. Mol Neurobiol. 56(6):4072-4085 doi: 10.1007/s12035-018-1358-4.
25. Shohayeb B, Lim NR, Ho U, Xu Z, Dottori M, Quinn L, Ng DCH. (2018). The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Mol Neurobiol. 55(7):5409-5424. doi: 10.1007/s12035-017-0778-x.
26. Ling Y,.. Xu Z*, Qin CF*. (2017). A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. SCIENCE eaam7120, DOI: 10.1126/science.aam7120 (Previewed or highlighted by Nature, Science, Nature Reviews Neurobiology, Nature Reviews Microbiology, PNAS et al., Covered by >100 media, including New York Times, Reuters, The Washington Post, Los Angeles Times, USA Today, NBC News, NPR, The Scientist, etc. 第一完成课题组)
27. Fan et al., Xu Z* (2017) Mea6 Deletion in Pancreatic β Cells Impairs Proinsulin Trafficking and Insulin Biogenesis in Mice. J Cell Biology DOI: 10.1083/jcb.201705027
28. Wang S., Hong S... Xu Z*. (2017) Transfer of Convalescent Serum to Pregnant Mice Prevents Zika Virus Infection and Microcephaly in Offspring. Cell Research doi:10.1038/cr.2016.144
29. Deng et al., Xu Z*, Qin CF*. (2017) Intranasal infection and contact transmission of Zika virus in guinea pigs. Nat. Commun. doi:10.1038/s41467-017-01923-4
30. Li C, Deng Y-Q, Wang S...Xu Z*, Qin C*, Cheng G*. (2017) 25-Hydroxycholesterol protects host against ZIKV infection and its associated microcephaly. Immunity 46(3):446-456. doi: 10.1016/j.immuni.2017.02.012
31. Oh Y et al., Xu Z*, Jin P*, Song H., Ming G-L*, Lee G*. (2017) Zika virus directly infects human peripheral neurons and induces cell death. Nature Neuroscience 20(9):1209-1212. doi: 10.1038/nn.4612.
32. Zhang et al., Xu Z* (2017) American Strain of Zika Virus Causes More Severe Microcephaly than an Old Asian Strain in neonatal Mice. EBioMedicine doi: 10.1016/j.ebiom.2017.10.019.
33. Li C, Zhu X,. .. Xu Z*, Cheng G*. (2017) Chloroquine, a FDA-approved Drug, Prevents ZIKV Infection and its Associated Congenital Microcephaly in Mice. EBioMedicine doi:10.1016/j.ebiom.2017.09.034
34. Yoon KJ, et al., Xu Z*, Qian J*, Zhu H*, Song H*, Ming G-L*. (2017) NS2A protein encoded by Zika virus disrupts mammalian cortical neurogenesis. Cell Stem Cell 21(3):349-358.e6. doi: 10.1016/j.stem.2017.07.014. (*Senior author)
35. Wang S....Z Xu and Z Fan. (2017) Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. CELL 171(1):201-216.e18. doi: 10.1016/j.cell.2017.07.027.
36. Xu D., Zhu Y., and Xu Z*. (2017) Efficient genetic manipulation in the developing brain of tree shrew using in utero electroporation and virus infection. J Genetics and Genomics doi: 10.1016/j.jgg.2017.09.007
37. Li C, Xu D, .. Qin C*, Xu Z*. (2016) Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell doi:10.1016/j.stem.2016.04.017 (Previewed or highlighted by Science, Nature Reviews Neurobiology, Nature Reviews Microbiology; Trends in Molecular Medicine, etc. Covered by >300 media, including BBC, Reuters, Los Angeles Times, USA Today, NBC News, Fox News, The Scientist, etc. ‘Best of Cell Stem Cell 2016’)
38. Zhang HS…. Xu Z*. (2016) Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat. Commun. doi: 10.1038/ncomms11773.
39. Wang Y, Liu L,.. Xu Z*. (2016) Mea6 controls VLDL transport through the coordinated regulation of COPII assembly. Cell Research doi:10.1038/cr.2016.75
40. Zhang F. Yu JW, Yang T. Xu D,.Xia YH., Xu Z*. (2016) A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. J Biol Chem pii: jbc.M116.716811. (Cover story, “Paper of the week” with editorial comments and highlight for the student)
41. Zhang L, Zhang F,... Xu Z*. (2016) The B cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration. J Mol Cell Biol. pii: mjw034
42. Xu D. and Xu Z*. (2016) Driving WDR62 to the Pole. Cell Cycle DOI:10.1080/15384101. 2016.1154374
43. Shao XM. et al., (2016) Numb Regulates Vesicular Docking for Homotypic Fusion of Early Endosomes via Membrane Recruitment of Mon1b. Cell Research doi: 10.1038/cr.2016.34
44. Liu B…Xu Z., ZhengYF. (2016) MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Reports 6:21534. doi: 10.1038/srep21534
45. Liu K, Lei R, Li Q, Wang XX, Wu Q, An P, Zhang J, Zhu M, Xu Z, Hong Y, Wang F, Shen Y, Li H, Li H. (2016) Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 6:21019. doi: 10.1038/srep21019
46. Li P… Xu Z*, and Zhu Z*. (2015) Epigenetic silencing of microRNA-149 in cancer associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment Cell Research 25(5):588-603
47. Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Xu Z, Bogoyevitch MA, Ng DC. (2015) Opposing roles for JNK and Aurora A in regulating WD40-Repeat Protein 62 association with spindle microtubules. J Cell Sci. 128:527-540
48. Zhang F. Xu D,. Sun YM., Xu Z*. (2014) Epigenetic regulation of Atrophin1 by lysine-specific demethylase is required for cortical progenitor maintenance. Nat. Commun, 5:5815. doi: 10.1038/ncomms6815
49. Xu D. Zhang F, Wang Y, Sun Y, Xu Z*. (2014) Microcephaly Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the developmental cortex. Cell Reports 6(1):104-16
50. Yu J, Zhang F, Zhang Y, Fan M and Xu Z* (2014) TAK1 is activated by TGF-β signaling and controls axonal growth during brain development. J Mol Cell Biol. 6(4):349-51.
51. Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, Yuan Z. (2014) BMP2-SMAD Signaling Represses the Proliferation of Embryonic Neural Stem Cells through YAP. J Neuroscience 34(36):12039-48
52. Zhu Y, Wang C, Yu M, and Xu Z*. (2013) ULK1 and JNK are Involved in Mitophagy Incurred by LRRK2 G2019S Expression. Protein Cell 4(9): 711-21.
53. Shi W, Chen Y, Gan G, Ren J, Wang Q, Xu Z, Xie X, and Zhang Y. (2013) Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing Mad expression. J Neuroscience 24;33(30):12352-63.
54. Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. (2013) HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. PNAS 19;110(12):4604-9.
55. Yang T., Sun YM…Xu Z* (2012) POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration. Cell Reports 2(3):640-51 (Article).
56. Wilhelm M, Kukekov NV, Schmit TL, Biagas KV, Sproul AA, Gire S, Maes ME, Xu Z, Greene LA.（2012）Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem. 287(3):2247-56.
57. J Niu, M Yu and Z Xu*. (2012) Leucine-Rich Repeat Kinase 2 (LRRK2) Disturbs Mitochondrial Dynamics via Dynamin-Like Protein (DLP1). J NeuroChem 122(3):650-8.
58. J Cui, M Yu, Z Xu* (2011). Expression of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibits the Processing of uMtCK to Induce Cell Death in cell culture model system. Biosci Rep 31(5):429-437.
59. Y Sun, T Fei, T Yang, F Zhang, Y Chen, Z Xu* (2010) The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 285(50): 39039–39050.
60. Ren J., Wang Y., Liang Y....and Xu Z* (2010) Methylation of ribosomal protein s10 by protein arginine methyltransferase 5 regulates ribosome biogenesis J Biol Chem. 285(17):12695-705.
61. C Wang, Y Tao, Y Wang, Z Xu* Regulation of the Protein Stability of POSH and MLK Family. Protein Cell 1(9): 871–878.
62. Y Sun, Z Xu* (2010) Regulation of Neural Stem Cell by Bone Morphogenic Protein (BMP) Signaling During Brain Development. Frontiers in Biology 5(5):380-385.
63. B Lu; Y Zhai, C Wu; X Pang, Z Xu, F Sun (2010) Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2. BBA-Proteins and Proteomics 804(9):1780-4.
64. M Zhang, Y Zhang and Z Xu* (2010) POSH is Involved in Egr-Bsk (TNF-JNK) Signaling and Embryogenesis in Drosophila. J Genetics and Genomics 37(9):605-19.
65. Shen Q, Qin F, Gao Z, Cui J, Xu Z, and Yang C (2009) Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegans. Mol Cell Biol, 29(14): 3881–3893.
66. Jin S, Pan L, Liu Z, Wang Q, Xu Z, and Zhang Y (2009) Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136(9):1571-81.
67. Sproul A , Xu Z and Greene L (2009) Cbl Negatively Regulates JNK Activation and Cell Death. Cell Research 19(8):950-61.
68. Liu S, Yu M, He Y, Xiao L,…, and Xu Z* (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 47(6) 1964-73.
69. Qiao HX, Hao CJ, Li Y, He X, Chen RS, Cui J, Xu Z*, Li W*.（2008） JNK activation mediates the apoptosis of xCT-deficient Cells. BBRC 370(4):584-8.
70. Sun Y, Yang T, Xu Z* (2007) The JNK Pathway and Neuronal Migration. J Genetics and Genomics 34(11): 957-965.
71. Wilhelm M, Kukekov NV, Xu Z, Greene LA (2007) Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH. Dev Neurosci. 29(4-5):355-62.
72. Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. (2007) Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon Cancer Cells. Cancer Res. 67(10):4700-4708.
73. Cui J, Zhang M, Zhang YQ, Xu Z* (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacol Sin. 28(5):601-8.
74. Welhelm M, Xu Z., and Greene L （2007）Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. J Biol Chem. 282(2):1288-95.
75. Xu Z.*, Sproul A., Wang WY, and Greene L. (2006) SIAH1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis. J Biol Chem. 281(1):303-12.
(* Corresponding author)
76. Kukekov, N*.,Xu Z.*, and Greene(2006) Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. J Biol Chem. 281(22):15517-24.
(* Equal contribution)
77. Tang G, Xu Z, Goldman JE. (2006) Synergistic effects of the SAPK/JNK & the proteasome pathways on GFAP accumulation in Alexander disease. J Biol Chem. 281(50):38634-43.
78. Xu Z.*, Kukekov, N., and Greene L (2005) A stability-based self-amplifying feed forward loop mechanism for regulation of the apoptotic JNK pathway. Mol Cell Biol. 25(22):9949-59.
(* Corresponding author)
79. Xu Z.* and Greene L. (2006) Activation of the apoptotic JNK pathway through the Rac1-binding scaffold protein POSH. Methods Enzymol 406:479-89. (* Corresponding author)
80. Zheng S.*, Xu Z.*¨, and Longey J. (2005) Cbl-b/Cbl regulates c-Kit receptor stability through the proteasomal pathway in mast cells. Blood 105(1):226-32. (* Equal contribution, ¨ Corresponding author).
81. Hanlon SE, Xu Z, Norris DN, Vershon AK. (2004) Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae. Yeast. 21(15):1241-52.
82. Kim K., Kim B., Xu Z, and Kim S. (2004). Mixed lineage kinase (MLK) 3-activated p38 MAP kinase mediates TGF-Beta-induced apoptosis in hepatoma cells. J Biol Chem. 279(28):29478-84.
83. Xu Z., Kukekov N., and Greene LA (2003). POSH (plenty of SH3’s) Acts as a Scaffold for a Multiprotein Complex that Mediates JNK Activation in Apoptotic Death. EMBO J 15; 22(2): 252-61.
84. Xu Z, Maroney AC, Dobrzanski P, Greene LA (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol. 21(14): 4713-24.
85. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL (2001). Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 276(27): 25302-8.
86. Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA (2001). beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem. 77(1):157-64.
87. Xu Z., and Norris D. (1999). The SFP1 gene product of S. cerevisiae regulates G2/M transitions in the mitotic cell cycle and in response to DNA damage. Genetics 150(4): 1419-28.
Academic Lecture Preview: October 14, 2021, 14:00, Researcher Xu Zhiheng (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences): Research on Brain Development and Brain Disease Mechanisms
Release time: 2021-10-11 Views: 87 times
Speaker: Researcher Xu Zhiheng
Event time: 14:00 on October 14, 2021
Venue: Tencent Conference, Conference ID: 841 345 836
Lecture Content: Brain Development and Brain Disease Mechanism Research
Speaker introduction:
Xu Zhiheng is a researcher and doctoral supervisor at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. He is the director of the Molecular Development Center of the Institute of Genetics and Development of the Chinese Academy of Sciences, the deputy director of the State Key Laboratory of Molecular Developmental Biology; the deputy director of the Neurodevelopment and Regeneration Branch and the Child Cognitive and Brain Dysfunction Branch of the Chinese Society of Neuroscience.
He graduated from Shanghai Second Military Medical University in 1989 and received his Ph.D. from Rutgers University in the United States in 1999. From 1999 to 2005, he worked as a postdoctoral fellow and senior research assistant at Columbia University, USA. He has successively won the Ruth L. Kirschstein National Research Service Award from the NIH in the United States, the "Hundred Talents Program" of the Chinese Academy of Sciences, the "Outstanding Youth" and Innovation Group (Chief) of the Fund Committee, and the 863 Project (Chief) of the Ministry of Science and Technology.
Mainly engaged in brain development and disease mechanism research. Published more than 60 papers as corresponding authors, including Science, Cell Stem Cell, Nature Neuroscience, Immunity, Nature Metabolism, Nature Communications (3 papers), Cell Reports (4 papers), PNAS, J Cell Biology, Cell Research (3 papers), Advanced Science, PLoS Biology, Blood, Hepatology, MCB (2 papers), JBC (6 papers), Annual Review Virology and other journals. The total impact factor of papers is > 480, and the citations are > 4600 times. The results were selected into the "2017 China's Major Science, Technology and Engineering Progress"; In terms of teaching, he has successively won the "Chinese Academy of Sciences Outstanding Mentor Award" (2019, 2021), "Tang Lixin Teaching Famous Teacher Award", "Zhu Liyuehua Outstanding Teacher Award", "Lingyan Award" and "Yihai Kerry Outstanding Teacher Award".
Latest research results of Zika virus released in Beijing
The research team of Xu Zhiheng, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and the research team of Qin Chengfeng, Institute of Microbial Epidemiology, Academy of Military Medical Sciences, established the first animal model of Zika virus microcephaly and confirmed that Zika virus can directly cause microcephaly. occur. In the early morning of May 12, Beijing time, the world-class academic journal "Cell Stem Cell" published the results online.
On the afternoon of May 11, the Bureau of Science Communication and the Institute of Genetic Development jointly organized a press conference on this scientific research achievement. People's Daily, Xinhua News Agency, Guangming Daily, Economic Daily, China Daily, China National Radio, China Central Television, Science and Technology Daily, China Youth Daily, China News Service, Wen Wei Po, China Science News and other media participated. Han Yibo, deputy director of the Institute of Genetics and Development, presided over the press conference. Director Yang Weicai first introduced the overall situation. Researcher Xu Zhiheng and researcher Qin Chengfeng of the Academy of Military Medical Sciences then released their research results and accepted media interviews.
Up to now, all participating media have broadcast reports, a total of more than 10 articles. Among them, People's Daily publishes reports and pushes them through its client, Xinhua News Agency broadcasts all media reports of pictures, texts and TV, CCTV's "News Network" and "Chaowen Tianxia" columns broadcast reports, and Science and Technology Daily and China Science News are published on the front page. report.
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