Benzhan Zhu, selected into the "Hundred Talents Program" of the Chinese Academy of Sciences,conducted a postdoctoral research at the Linus Pauling Institute in the United States and has received NIH fund

Name: Zhu Benzhan [doctoral supervisor]Sex: MaleTitle: ResearcherTel: 62849030E-mail：bzhu@rcees.ac.cnGroup: Free Radical Chemistry and Compound Toxicology Research GroupResearch Interests: Chemical and Toxicological Synergistic Toxicity Mechanisms of Free Radicals and Transition Metal IonsAdmissions majors: Organic Chemistry, Synthesis, Computing, Mechanistic Molecular Biology, Toxicology, Genetics, Medicine

CV:

        Zhu Benzhan is a researcher and doctoral supervisor of the State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. He received his master's degree from Lanzhou Institute of Chemistry, Chinese Academy of Sciences in 1989, and his Ph.D. degree in biochemistry from Hebrew University in Jerusalem - Hadassah Medical School in 1999. In July 1999, he conducted a postdoctoral research at the Linus Pauling Institute in the United States, and was promoted to a senior research assistant professor in July 2002. In 2006, he was selected into the "Hundred Talents Program" of the Chinese Academy of Sciences and was rated as "Excellent" in the final evaluation. In 2009, it was supported by the "Outstanding Youth Fund" of the National Foundation Committee. Mainly engaged in the synergistic toxicity mechanism of complex environmental pollutants, free radicals, transition metal ions and natural antioxidants chemistry, biochemistry and toxicology research, carried out some pioneering research work. One of the main academic achievements is the discovery of a new mechanism of toxicity, namely the formation and synergistic toxicity of lipophilic adducts; since he was selected into the "Hundred Talents Program" of the Chinese Academy of Sciences and returned to work in 2006, he has discovered a new type of Fenton that is different from the classic Fenton. ) reaction of novel hydroxyl and alkoxy radical generation mechanism: PTS carcinogenic halogenated quinone metabolites react with hydrogen peroxide to generate hydroxyl radicals, but this reaction does not depend on the presence of metal ions. This mechanism can partially explain the carcinogenicity of PTS such as polyhalophenols; a new class of carbon-centered quinone radicals was detected for the first time for the previously proposed haloquinone-mediated metal ion-independent hydroperoxide decomposition The mechanism provides the most direct and conclusive experimental evidence; a novel molecular reaction mechanism for the detoxification of polyhalogenoquinones by hydroxamic acids was discovered: an extraordinary class of Lossen rearrangements that can proceed under mild conditions, which It can occur under normal physiological conditions, and it is a two-step continuous rearrangement reaction; a new type of hydroxyl radical-dependent secondary chemiluminescence generation system has been discovered, and a new molecular mechanism of chemiluminescence has been proposed. The above systematic research results have enriched and developed the classical hydroxyl radical generation theory, made important breakthroughs in the generation mechanism of PTS radicals, and promoted and led the development of pollutant radical chemistry. Published five papers in a row (the first and corresponding author). Due to the influence on free radical chemistry and toxicology, in July 2007, he was invited to give a 50-minute conference report at the famous "Gordon Research Conference"; in October 2008, he was invited to give a presentation at the "14th International Free radical Research Conference". 30-minute conference report; relevant results were written into the textbook "Free Radicals in Biology and Medicine". In 2008, he was invited to be the editorial board member and special editor of "Science Bulletin", and in January 2009, he was invited to become the international editorial board member of Chem. Res. Toxicol., a famous toxicology journal of the American Chemical Society (2011 impact factor was 3.779). He is currently a member of the "Biological and Medical Free Radicals" of the Chinese Society of Biophysics and the professional committee of "Analytical Toxicology" of the Chinese Society of Toxicology. As the main applicant, he has received funding from the National Institutes of Health and obtained a US patent as one of the main inventors. He has received funding and awards from UNESCO, European Society of Toxicology and other organizations. He has published more than 40 papers in free radical chemistry and compound toxicology, and has been cited more than 600 times by him in the SCI online version. 

Social service:

2008 Invited to be the editorial board member and contributing editor of "Science Bulletin"

In 2009, he was invited to be the editorial board member of Chem. Res. Toxicol. "Chemical Toxicology Research", a famous toxicological journal of the American Chemical Society, and the special guest editor of "China Special Issue".

In 2009, he was elected as a member of the "Biological and Medical Free Radical Professional Committee" of the Chinese Biophysical Society

2010 Invited to be the editorial board member of "Environmental Chemistry"

In 2013, he served as the director of the Eco-Environmental Research Center of the Chinese Academy of Sciences and the Joint Institute of Environmental Science of Baptist University

Undertake scientific research projects:

1. Chinese Academy of Sciences Strategic Pilot Science and Technology Project (Class B) XDB14030100 Environmental Exposure and Health Hazard Mechanisms of Typical Pollutants
2. General Program of National Natural Science Foundation of China, 21477139, Molecular mechanism and application of chemiluminescence of halogenated aromatic hydrocarbons during advanced oxidation process 2015/01-2018/12, 950,000, research principal
3. National Natural Science Foundation of China Innovation Group Project, 21321004, Environmental Processes and Toxicological Effects of Persistent Toxic Pollutants, 2014/01-2016/12, RMB 6 million, under research, in charge
4. Key Project of National Natural Science Foundation of China, 21237005, Study on the mechanism of synergistic toxicity between organic pesticides and inorganic pesticides containing copper and zinc, 2013/01-2017/12, 3 million yuan, in research, in charge
5. National Science Foundation for Distinguished Young Scholars, 20925724, Environmental Chemistry, 2010/01-2013/12, 2 million, in research, in charge
6. General Program of National Natural Science Foundation of China, 20877081, Research on the mechanism of synergistic toxicity of organic and inorganic wood protectants, 2009/01-2011/12, 300,000, completed, presided over
7. 973 Project, 2008CB418106, Research on the mechanism of cyanobacterial blooms in large and medium-sized shallow lakes, 2008/01-2012/12, 500,000, completed, the person in charge of the sixth project
8. General Program of National Natural Science Foundation of China, 20777080, Research on the formation of metal ion-independent hydroxyl radicals and the mechanism of DNA damage, 2008/01-2010/12, 300,000, completed, presided over
9. National Natural Science Foundation of China Innovation Group Project 20921063, Forms, Environmental Processes and Toxicological Effects of Persistent Toxic Pollutants, 2008/01-2009/12, 550,000, completed, participated
10. Chinese Academy of Sciences "Hundred Talents Program" project, free radical chemistry, 2006/06-2010/05, 2 million, completed, presided over

Awards and Honors:

He has received funding and awards from NIH in the United States, UNESCO, European Society of Toxicology and Hebrew University in Israel.

Representative works:

1. Zhu B.Z., Chao X.J., Huang C.H., Li Y. (2016) Delivering the cell-impermeable DNA ‘light-switch’ Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method. Chem. Sci
2. Mao, L., Huang, C.H., Gao, H.Y., Kalyanaraman, B., Zhu, B.Z. (2015) Intrinsic chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens. Environ. Sci. Technol. 49: 7940-7947.
3. Huang, C.H.; Ren, F.R.; Shan, G.Q.; Qin, H.; Mao, L.; Zhu, B.Z. (2015) Molecular mechanism of metal-independent decomposition of organic hydroperoxides by the halogenated quinoid carcinogens and the potential biological implications. Chem. Res. Toxicol., 28, 831-837.  (Cover story)
4. Zhu B.Z., Hollenberg PF (2015) Chemical toxicology in China: A special issue. Chem. Res. Toxicol.28: 279-280. (Guest Editor’s Editorial)
5. Shan GQ, Yu A, Zhao QF, Huang CH, Zhu LY, Zhu B.Z. (2015)A combined experimental and computational investigation on the unusual molecular mechanism of Lossen rearrangement reaction activated by the carcinogenic halogenated quinones. J. Org. Chem. 80: 180-189.
6. Li Y, Huang CH, Liu YX, Mao L, Zhu B.Z. (2014) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure Chemistry-A European Journal, 20(40):13028-33.
7. Shan G, Ye M, Zhu B, Zhu L.(2013) Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells. Chemosphere. 93(9):2101-7.
8. Huang, C. H.; Shan, G. Q.; Mao, L.; Kalyanaraman, B.; Qin, H.; Ren, F. R.; Zhu, B. Z. (2013) The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. Chem. Commun. 49: 6436-6438,
9. Qin H, Huang CH, Mao L, Xia HY, Kalyanaraman B, Shao J, Shan GQ, Zhu BZ. (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63，459-466.
10. Shao J, Huang CH, Kalyanaraman B, Zhu B.Z. (2013) Potent methyl oxidation of 5-methyl-2’-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60, 177-182.
11. Sheng ZG, Li Y, Fan RM, Chao XJ, Zhu B.Z. (2013) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual Lipophilic ternary complex. Toxicol. Appl. Pharmacol. 266: 335-344.
12. Sheng ZG, Huang W, Liu YX, Yuan Y, Zhu B.Z. (2013) Ofloxacin induces NADPH oxidase-driven ROS accumulation via β1 integrin-EGFR-Rac1 pathway in microencapsulated chondrocytes. Toxicol. Appl. Pharmacol. 266: 74-87.
13. Sheng ZG, Tang Y, Liu YX, Zhu BZ. (2013) Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression. Toxicol. Appl. Pharmacol. 266: 335-344.
14. Zhu B.Z., Mao L., Huang C.H., Qin H., Fan R.M., Kalyanaraman B., Zhu J.G. (2012) Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. Proc. Natl. Acad. Sci. USA 109: 16046-16051.
15. Zhu B.Z., Zhu J.G., Kalyanaraman B., Mao L. and Shan G.Q. (2010) Detoxifying polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement. Proc. Natl. Acad. Sci. USA 107: 20286-20290.