Jian Yang, now a grant reviewer for the US NIH and professor of Columbia University, is serving as researcher and director at Kunming Institute of Zoology, Chinese Academy of Sciences

 

Yang Jian Male Doctoral Supervisor Columbia University
Email: jianyang@mail.kiz.ac.cn Mailing
address: No. 32 Jiaochang East Road, Kunming, Yunnan Province
Postal Code: 650223

Research areas

Neurobiology and Biophysics, mainly engaged in the comprehensive research of voltage-gated calcium channels (VGCC) and transient receptor potential (TRP) channels, using methods including molecular biology, biochemistry, cell biology, patch clamp, X-ray crystallography The structure (including three-dimensional crystal structure), function and regulation of these two types of ion channels are systematically studied by means of science, optical imaging and other methods, and the gene mutation or malfunction of these channels is analyzed at the molecular level, cellular level and animal level. The pathogenesis of human diseases (such as neurodegenerative diseases including Alzheimer's disease, epilepsy, autism, dwarfism, polycystic kidney disease, etc.) Quantitative screening techniques are used to develop active molecules and drugs that target these channels.

Admissions Information

   

Admissions Major

071010 - Biochemistry and Molecular Biology

Admissions direction

Ion channel structure, function, disease mechanism and drug development

Education background

1987-09--1991-06 Ph.D., University of Washington, Seattle, USA 1985-12--1987-08
, Visiting Scholar, Colorado State University , USA Bachelor of Peking University

work experience

   

resume

2011-07~present, Kunming Institute of Zoology, Chinese Academy of Sciences, Researcher
2009-06~present, Columbia University, USA, Professor
2002-04~2009-05, Columbia University, USA, Associate Professor
1997-01~2002-04, Columbia University, USA, Assistant Professor
1994-01~1996-12, University of California, San Francisco and Howard Hughes Medical Institute, Postdoc
1991-08~1993-12, Stanford University, Postdoc

Social work

2015-08-01-present, Journal of Physiology (London), Journal editorial
board2015-07-31-present, Channels (Canada), journal editorial
board2015-06-01-present, Ad hoc member, NTRC study section, NIH, Fund Judge
2014-06-01-now, Zoological Research, Journal Editorial Board
2004-02-01-now, Ad hoc member, NTRC study section, NIH, Fund Judge

Patents and Awards

   

Patent achievements

(1) The role of the spider agaric enemyterpene in the preparation of N-type calcium channel inhibitors, Invention, 2015, 2nd author, Patent No.: CN104721180A

Publication information

   

Published papers

(1) Pepluanols C−D, Two Diterpenoids with Two Skeletons from Euphorbia peplus, Organic Letters, 2018, 6th author
(2) Valepotriates From the Roots and Rhizomes of Valeriana jatamansi Jones as Novel N-Type Calcium Channel Antagonists, Frontiers in Pharmacology , 2018, Corresponding author
(3) Structure of a eukaryotic cyclic nucleotide-gated channel, Nature, 2017, Corresponding author
(4) Structural basis of Ca2+/pH dual regulation of the endolysosomal Ca2+ channel TRPML1, Nat. Struc. Mol. Biol. , 2017, Corresponding author
(5) Clinical and mechanistic study of Bingpian, a topical analgesic in traditional Chinese medicine, EMBO Mol. Med., 2017, Corresponding author
(6) Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states , nature structure & molecular biology, 2017, corresponding author
(7) (±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum, Organic Letters., 2016, corresponding author
(8) Three minor diterpenoids with three unprecedented carbon skeletons from Euphorbia peplus, Org. Lett., 2016, communication Author
(9) TRPA1 and TRPV1 mediate the iodine antiseptics associated pain and allergy, EMBO Reports, 2016, corresponding author
(10) Two New Classes of T-Type Calcium Channel Inhibitors with New, organic letter, 2015, corresponding author
(11) Age -related homeostatic midchannel proteolysis of L-type voltage-gated Ca2+ channels, Neuron, 2014, corresponding author
(12) Molecular determinants of Gem inhibition of P/Q-type voltage-gated Ca2+ channels., Journal of Biological Chemistry, 2012, communication author
(13) Molecular mechanism of the assembly of an acid-sensing receptor/ion channel complex., Nature Communications. , 2012, corresponding author
(14) A structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach., Proc. Natl. Acad. Sci. , 2011, corresponding author

Research activities

   

scientific research projects

(1) Activity Screening of Calcium Ion Channels and Transient Receptor Potential Channels and Research on Action Mechanisms, Principal, Provincial, 2011-10--2014-12
(2) Structure, Function and Drug Development of Ion Channels, Principal, Provincial, 2011-10--2014-12
(3) Molecular Basis of TRPML1 Channel in Lysosomal Physiological Function and Disease Mechanism, Host, National Level, 2014-01--2017-12
(4) Important Novel Membrane Ion Channel Gating and Structural Basis of Regulatory Mechanisms, Chair, National Level, 2014-01--2018-08
(5) Ion Channel Drug Research and Development System, Participation, Ministries, 2013-01--2015-12
(6) Ion Channel-Targeted Establishment and application of cardiovascular and cerebrovascular drug screening and toxicity assessment models and methods, presided over, provincial level, 2015-01--2018-12
(7) The discovery and application of natural active molecules in cardiovascular and cerebrovascular diseases targeting ion channels Research on the drug-like properties of the antiarrhythmic lead molecules AA-1 and AA-2, chair, ministerial level, 2016-11--2018-06
(8) Research on the pharmacological mechanism of traditional Chinese medicine wormwood, participation, provincial level, 2018 -06--2021-05

Participate in meetings

(1) Structural basis of function and regulation of the endolysosomal calcium channel TRPML3 2018-11-29
(2) Structural basis of function and regulation of endolysosomal TRPML channels 2018-11-28
(3) Ion channel-targeting natural compounds and structural basis of modulation of an endolysosomal calcium channel 2018-11-16
(4) Ion channels and human health 2018 Shanghai International Orthopaedic Summit 2018-09-12
(5) Structural basis of function and regulation of the endolysosomal calcium channel TRPML3 2018-07- 26
(6) Cryo-EM structures of the endolysosomal calcium channel TRPML3 in the open, closed and low pH-inhibited states 2018-07-14
(7) Antiarrhythmic natural compounds and structural basis of modulation of an endolysosomal calcium channel 2018-06- 08
(8) Structures of the endolysosomal calcium channel TRPML3 in three distinct states reveal mechanisms of activation and regulation 2018-05-18
(9) Structures of the endolysosomal calcium channel TRPML3 in three distinct states reveal mechanisms of activation and regulation 2018-03-14
(10) The 6th International Conference on Ion Channels 2017-06-23
(11) 1. Structural basis of assembly and regulation of TRP channels The 5th International Conference on Ion Channels 2016-06-26

guide students

Students have been instructed

Ye Chenjun Postgraduate 071009-Cell Biology  

Guo Hongzhao Postgraduate 071007-Genetics  

Su Deyuan Master 071010-Biochemistry and Molecular Biology  

Xu Zhichun Master 071010-Biochemistry and Molecular Biology  

Li Huan PhD candidate 071006-Neurobiology  

Li Wenyan Postgraduate 071010-Biochemistry and Molecular Biology  

Hu Jinsheng Master 071010-Biochemistry and Molecular Biology  

Currently guiding students

Du Shuzong Master 071010-Biochemistry and Molecular Biology  

Tian Weifeng Ph.D. 071009-Cell Biology  

Research Team -- Ion Channel Drug Development Research Group

Researcher   Yang Jian Position: Director of Center for Ion Channel Drug Research and Development telephone: +86 871 65189257 fax: 0871-65199941 e-mail: jianyang@mail.kiz.ac.cn mailing address: No. 32 Jiaochang East Road, Kunming City, Yunnan Province 650223 Other homepages: http://internal.kiz.ac.cn/icdc/   CV Visiting researcher, currently director of ion channel drug research and development center, professor of the Department of Biological Sciences, Columbia University, USA. Since 1978, he has successively studied at Peking University, Shanghai Institute of Brain Research, Chinese Academy of Sciences, University of Washington in Seattle, Stanford University, University of California, San Francisco and other institutions of higher learning. As an associate professor, he became a professor in 2009. Received Scholar Awards from the Sloan, EJLB and McKnight Foundations and the American College of Cardiology Scholar Achievement Award. He has served as a grant reviewer for the National Institutes of Health (NIH) and an editorial board member for the Biophysical Journal. Published papers in internationally renowned academic journals such as Physiological Reviews, Nature, Nature Neuroscience, Neuron, and PNAS. Education and work experience 1978.9 -1982.7 Peking University, Department of Biology, Department of Biophysics, Bachelor of Science 1982.8 -1985.7 Shanghai Institute of Brain Research, Chinese Academy of Sciences, Neurophysiology, Master of Science Instructor : Professor Shen Kefei 1985.12-1987.8 Colorado State University, USA, Department of Anatomy and Neurobiology, Visiting Scholar   Supervisor: Professor Stephen D. Roper 1987.9-1991.6 University of Washington, Seattle, USA, Department of Physiology and Biophysics, PhD Supervisor: Professor Bertil Hille 1991.8-1993.12 Stanford University, USA, Department of Molecular and Cellular Physiology , Postdoctoral Supervisor: Professor Richard W. Tsien (Qian Yongyou) 1994.1-1996.12 University of California, San Francisco and Howard Hughes Medical Institute, Postdoctoral Supervisor: Professor Lily Y. Jan (Ye Gongzhu) 1997.1-2002.4 Columbia University, Biology Department of Science, Assistant Professor 2002.4-2009.5 Columbia University, USA, Department of Biology, Associate Professor 2009.6- present Columbia University, USA, Department of Biology, Professor 2011.7- present Visiting Researcher at Kunming Institute of Zoology, Chinese Academy of Sciences   research direction Neurobiology and Biophysics, mainly engaged in the comprehensive research of voltage-gated calcium channels (VGCC) and transient receptor potential (TRP) channels, using methods including molecular biology, biochemistry, cell biology, patch clamp, X-ray crystallography The structure (including three-dimensional crystal structure), function and regulation of these two types of ion channels are systematically studied by means of science, optical imaging and other methods, and the gene mutation or malfunction of these channels is analyzed at the molecular level, cellular level and animal level. The pathogenesis of human diseases (such as neurodegenerative diseases including Alzheimer's disease, epilepsy, autism, dwarfism, polycystic kidney disease, etc.) Quantitative screening techniques are used to develop active molecules and drugs that target these channels.   Expert category researcher   Awards and Honors 1997 Sloan Research Award 2000 McKnight Scholar Award 2001 EJLB Scholar Award 2004 Scholar Achievement Award, American College of Cardiology   representative works 1. Fan, Mm., Zhang, WK, Buraei, Z., and Yang, J. (2012). Molecular determinants of Gem inhibition of P/Q-type voltage-gated Ca2+ channels. J. Biol. Chem. In press 2. Zhu, J.*, Yu, Y.*, Ulbrich, MH, Li, Mh., Isacoff, EY, Honig, B., and Yang, J. (2011). A structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc. Natl. Acad. Sci. 108, 10133-10138. 3. Li, Mh., Yu, Y., and Yang, J. (2011) . Structural biology of TRP channels. Adv. Exp. Med. Biol., 704, 1-23. 4. Buraei, Z., and Yang, J. (2010). The ? subunit of voltage-gated Ca2+ channels. Physiological Reviews. 90, 1461-1506. 5. Fan, Mm.*, Buraei, Z.*, Luo, HR., Levenson-Palmer, R., and Yang, J. (2010). Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavβ interaction. Proc. Natl. Acad. Sci. 107, 14887-14892. 6. Zhang, Y., Yamada, Y., Fan, M., Bangaru, SD, Lin, B., and Yang, J. (2010). The β-subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6. J. Biol. Chem. 285, 2527-2536. 7. Yu, Y. , Ulbrich, MH, Li, Mh., Chen, XZ., Ong, ACM, Tong, L., Isacoff, EY, and Yang, J. (2009). Structural and molecular basis of the assembly of the TRPP2/PKD1 complex . Proc. Natl. Acad. Sci. 106, 11558-11563. 8. Zhang, Y., Chen, Yh., Bangaru, SD, Abele, K., Tanabe, S., Kozasa, T., and Yang, J. (2008). Origin of the voltage-dependence of G protein regulation of P/Q-type Ca2+ channels. J. Neurosci. 28, 14176-14188. 9. He, Ll., Zhang, Y., Chen, Yh., Fitzmaurice, A., and Yang, J. (2007). Functional modularity of the ? subunit of voltage-gated Ca2+ channels. Biophysical Journal 93, 834-845. 10. Michailidis, Y., Zhang, Y., and Yang, J. (2007). The lipid connection - Regulation of voltage-gated Ca2+ channels by phosphoinositides . Pflugers Ach. 455, 147-155. 11. Chen, Yh., Li, Mh., Zhang, Y., He., Ll., Yamada, Y., Fitzmaurice, A., Shen, Y., Zhang, H., Tong, L., and Yang, J. (2004). Structural basis of the ? 1? ? interaction of voltage-gated Ca2+ channels. Nature 429, 675-680. 12. Xiao, J., Zhen, XG., and Yang, J. (2003). Localization of PIP2 activation gate in inward rectifier K+ channels. Nature Neurosci. 6, 811-818. 13. Wu, L.*, Bauer , C*., Zhen, XG., Xie, C., and Yang, J. (2002). Dual regulation of voltage-gated calcium channels by PIP2. Nature 419, 947-952.